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10.1021/acsomega.8b00637

http://scihub22266oqcxt.onion/10.1021/acsomega.8b00637
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suck abstract from ncbi


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pmid31458988      ACS+Omega 2018 ; 3 (8): 8589-8594
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  • Zirconyl Clindamycinphosphate Antibiotic Nanocarriers for Targeting Intracellular Persisting Staphylococcus aureus #MMPMID31458988
  • Heck JG; Rox K; Lunsdorf H; Luckerath T; Klaassen N; Medina E; Goldmann O; Feldmann C
  • ACS Omega 2018[Aug]; 3 (8): 8589-8594 PMID31458988show ga
  • [ZrO](2+)[CLP](2-) (CLP: clindamycinphosphate) inorganic-organic hybrid nanoparticles (IOH-NPs) represent a novel strategy to treat persisting, recurrent infections with multiresistant Staphylococcus aureus. [ZrO](2+)[CLP](2-) is prepared in water and contains the approved antibiotic with unprecedented high load (82 wt % CLP per nanoparticle). The IOH-NPs result in 70-150-times higher antibiotic concentrations at difficult-to-reach infection sites, offering new options for improved drug delivery for chronic and difficult-to-treat infections.
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