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10.1152/physrev.00038.2018 http://scihub22266oqcxt.onion/10.1152/physrev.00038.2018 31437091!6985785!31437091     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Physiol+Rev 2020 ; 100 (1): 211-269 Nephropedia Template TP {{tp|p=31437091|t=2020. Extracellular Nucleotides and P2 Receptors in Renal Function |pdf=|usr=}}{{31437091}} gab.com Text Extracellular Nucleotides and P2 Receptors in Renal Function JO: Physiol Rev http://www.kidney.de/pget.php?&tw=1&pmid=31437091 #FOAvip The understanding of the nucleotide/P2 receptor system in the regulation of renal hemodynamics and transport function has grown exponentially over the last 20 yr. This review attempts to integrate the available data while also identifying areas of missing information. First, the determinants of nucleotide concentrations in the interstitial and tubular fluids of the kidney are described, including mechanisms of cellular release of nucleotides and their extracellular breakdown. Then the renal cell membrane expression of P2X and P2Y receptors is discussed in the context of their effects on renal vascular and tubular functions. Attention is paid to effects on the cortical vasculature and intraglomerular structures, autoregulation of renal blood flow, tubuloglomerular feedback, and the control of medullary blood flow. The role of the nucleotide/P2 receptor system in the autocrine/paracrine regulation of sodium and fluid transport in the tubular and collecting duct system is outlined together with its role in integrative sodium and fluid homeostasis and blood pressure control. The final section summarizes the rapidly growing evidence indicating a prominent role of the extracellular nucleotide/P2 receptor system in the pathophysiology of the kidney and aims to identify potential therapeutic opportunities, including hypertension, lithium-induced nephropathy, polycystic kidney disease, and kidney inflammation. We are only beginning to unravel the distinct physiological and pathophysiological influences of the extracellular nucleotide/P2 receptor system and the associated therapeutic perspectives. Twit Text FOAVip Extracellular Nucleotides and P2 Receptors in Renal Function ????Physiol Rev http://www.kidney.de/pget.php?&tw=1&pmid=31437091 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=31437091 #FOAvip English Wikipedia <ref>{{Cite pmid|31437091}}</ref> Extracellular Nucleotides and P2 Receptors in Renal Function #MMPMID31437091 Vallon V; Unwin R; Inscho EW; Leipziger J; Kishore BK Physiol Rev 2020[Jan]; 100 (1): 211-269 PMID31437091show ga The understanding of the nucleotide/P2 receptor system in the regulation of renal hemodynamics and transport function has grown exponentially over the last 20 yr. This review attempts to integrate the available data while also identifying areas of missing information. First, the determinants of nucleotide concentrations in the interstitial and tubular fluids of the kidney are described, including mechanisms of cellular release of nucleotides and their extracellular breakdown. Then the renal cell membrane expression of P2X and P2Y receptors is discussed in the context of their effects on renal vascular and tubular functions. Attention is paid to effects on the cortical vasculature and intraglomerular structures, autoregulation of renal blood flow, tubuloglomerular feedback, and the control of medullary blood flow. The role of the nucleotide/P2 receptor system in the autocrine/paracrine regulation of sodium and fluid transport in the tubular and collecting duct system is outlined together with its role in integrative sodium and fluid homeostasis and blood pressure control. The final section summarizes the rapidly growing evidence indicating a prominent role of the extracellular nucleotide/P2 receptor system in the pathophysiology of the kidney and aims to identify potential therapeutic opportunities, including hypertension, lithium-induced nephropathy, polycystic kidney disease, and kidney inflammation. We are only beginning to unravel the distinct physiological and pathophysiological influences of the extracellular nucleotide/P2 receptor system and the associated therapeutic perspectives. |*Signal Transduction[MESH] |Adenosine Triphosphate/metabolism[MESH] |Animals[MESH] |Humans[MESH] |Kidney/*metabolism/physiology[MESH] |Nucleotides/*metabolism[MESH]Extracellular Nucleotides and P2 Receptors in Renal Function (epmc).pdf DeepDyve Pubget Overpricing