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10.12932/AP-190717-0118

http://scihub22266oqcxt.onion/10.12932/AP-190717-0118
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31421659!ä!31421659

suck abstract from ncbi


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pmid31421659      Asian+Pac+J+Allergy+Immunol 2022 ; 40 (1): 31-38
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  • Comparison efficacy of randomized nebulized magnesium sulfate and ipratropium bromide/fenoterol in children with moderate to severe asthma exacerbation #MMPMID31421659
  • Wongwaree S; Daengsuwan T
  • Asian Pac J Allergy Immunol 2022[Mar]; 40 (1): 31-38 PMID31421659show ga
  • BACKGROUND: In Thailand, nebulized ipratropium bromide/fenoterol, is commonly used in addition to salbutamol for severe asthma exacerbation. Recently, nebulized MgSO4 is indicated in GINA 2015 as an additive treatment for severe cases. However, there is limited data showed the efficacy of both drugs in childhood severe asthma. The purpose of this study to compare efficacy and safety of nebulized MgSO4 and ipratropium bromide/fenoterol in moderate to severe asthma attacks. METHODS: In this a prospective, double-blind, randomized, controlled trial study, we enrolled thirty-three children, age ranged from 2 to 15 years old, with PRAM score >/= 4 (moderate to severe asthma exacerbation) despite 3 doses of nebulized salbutamol. Each patient was randomized to receive either three doses of nebulized MgSO4 or nebulized ipratropium bromide/fenoterol every 30 minutes. The PRAM score was measured at 0, 30, 60, 90, 120 and 240 minutes after the treatment. The adverse event and admission days were also evaluated. RESULTS: Sixteen patients received nebulized MgSO4 and seventeen received nebulized ipratropium bromide/fenoterol. Almost patients were classified as having moderate asthmatic attack. There were no statistically significant difference between the two study groups in almost baseline characteristic, PRAM score at 0, 30, 60, 90, 120, 240 minutes. The hospital length of stay was also similar between two groups (p = 0.83). There were no serious events in both groups. CONCLUSIONS: Our double blind, randomized, controlled pilot study demonstrated non-inferior outcomes including clinical benefit and safety of nebulized MgSO4 and nebulized ipratropium bromide/fenoterol among Thai children with acute moderate asthmatic.
  • |*Asthma/drug therapy[MESH]
  • |*Ipratropium/therapeutic use[MESH]
  • |Administration, Inhalation[MESH]
  • |Adolescent[MESH]
  • |Albuterol/therapeutic use[MESH]
  • |Bronchodilator Agents[MESH]
  • |Child[MESH]
  • |Child, Preschool[MESH]
  • |Double-Blind Method[MESH]
  • |Drug Therapy, Combination[MESH]
  • |Fenoterol/therapeutic use[MESH]
  • |Humans[MESH]
  • |Magnesium Sulfate/adverse effects[MESH]


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