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10.1371/journal.pgen.1008336 http://scihub22266oqcxt.onion/10.1371/journal.pgen.1008336 31415562!6711546!31415562     free     free     free       PLoS+Genet 2019 ; 15 (8): e1008336 Nephropedia Template TP {{tp|p=31415562|t=2019. Genetic screens reveal novel major and minor players in magnesium homeostasis of Staphylococcus aureus |pdf=|usr=}}{{31415562}} gab.com Text Genetic screens reveal novel major and minor players in magnesium homeostasis of Staphylococcus aureus JO: PLoS Genet http://www.kidney.de/pget.php?&tw=1&pmid=31415562 #FOAvip Magnesium is one of the most abundant metal ions in living cells. Very specific and devoted transporters have evolved for transporting Mg2+ ions across the membrane and maintain magnesium homeostasis. Using genetic screens, we were able to identify the main players in magnesium homeostasis in the opportunistic pathogen Staphylococcus aureus. Here, we show that import of magnesium relies on the redundant activity of either CorA2 or MgtE since in absence of these two importers, bacteria require increased amounts of magnesium in the medium. A third CorA-like importer seems to play a minor role, at least under laboratory conditions. For export of magnesium, we identified two proteins, MpfA and MpfB. MpfA, is the main actor since it is essential for growth in high magnesium concentrations. We show that gain of function mutations or overexpression of the minor factor, MpfB, which is part of a sigmaB controlled stress response regulon, can compensate for the absence of MpfA. Twit Text FOAVip Genetic screens reveal novel major and minor players in magnesium homeostasis of Staphylococcus aureus ????PLoS Genet http://www.kidney.de/pget.php?&tw=1&pmid=31415562 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=31415562 #FOAvip English Wikipedia <ref>{{Cite pmid|31415562}}</ref> Genetic screens reveal novel major and minor players in magnesium homeostasis of Staphylococcus aureus #MMPMID31415562 Trachsel E; Redder P; Linder P; Armitano J PLoS Genet 2019[Aug]; 15 (8): e1008336 PMID31415562show ga Magnesium is one of the most abundant metal ions in living cells. Very specific and devoted transporters have evolved for transporting Mg2+ ions across the membrane and maintain magnesium homeostasis. Using genetic screens, we were able to identify the main players in magnesium homeostasis in the opportunistic pathogen Staphylococcus aureus. Here, we show that import of magnesium relies on the redundant activity of either CorA2 or MgtE since in absence of these two importers, bacteria require increased amounts of magnesium in the medium. A third CorA-like importer seems to play a minor role, at least under laboratory conditions. For export of magnesium, we identified two proteins, MpfA and MpfB. MpfA, is the main actor since it is essential for growth in high magnesium concentrations. We show that gain of function mutations or overexpression of the minor factor, MpfB, which is part of a sigmaB controlled stress response regulon, can compensate for the absence of MpfA. |Cation Transport Proteins/genetics/*metabolism[MESH] |Gain of Function Mutation[MESH] |Homeostasis[MESH] |Magnesium/*metabolism[MESH] |Regulon/*genetics[MESH]Genetic screens reveal novel major and minor players in magnesium home(epmc).pdf DeepDyve Pubget Overpricing