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10.2147/IJN.S214363 http://scihub22266oqcxt.onion/10.2147/IJN.S214363 31413570!6662177!31413570     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=31413570&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Int+J+Nanomedicine 2019 ; 14 (?): 5697-5711 Nephropedia Template TP {{tp|p=31413570|t=2019. The relative effects of Ca and Mg ions on MSC osteogenesis in the surface modification of microrough Ti implants |pdf=|usr=}}{{31413570}} gab.com Text The relative effects of Ca and Mg ions on MSC osteogenesis in the surface modification of microrough Ti implants JO: Int J Nanomedicine http://www.kidney.de/pget.php?&tw=1&pmid=31413570 #FOAvip PURPOSE: Calcium (Ca) and magnesium (Mg) ions have been used as promising bioactive ions in the surface chemistry modification of titanium (Ti) bone implants to increase bone regeneration capacity. However, it is not clear which (Ca or Mg) plays the more important role in the early osteogenic differentiation of mesenchymal stem cells (MSCs) when applied to the surface of commercially available microstructured Ti implants. This study investigated the relative effect of these two ions on the early osteogenic functionality of primary mouse bone marrow MSCs in order to obtain insights into the surface design of Ti implants with enhanced early osteogenic capacity. METHODS AND RESULTS: Wet chemical treatment was performed to modify a microrough Ti implant surface using Ca or Mg ions. Both the Ca and Mg-incorporated surfaces accelerated early cellular events and the subsequent osteogenic differentiation of MSCs compared with an unmodified microrough Ti surface. Surface Mg modification exhibited a more potent osteoblast differentiation-promoting effect than the Ca modification. Surface Mg incorporation markedly inhibited the phosphorylation of beta-catenin. CONCLUSION: These results indicate that alteration of the surface chemistry of microstructured Ti implants by wet chemical treatment with Mg ions exerts a more effect on promoting the early osteogenic differentiation of MSCs than Ca ions by enhancing early cellular functions, including focal adhesion development and stabilization of intracellular beta-catenin. Twit Text FOAVip The relative effects of Ca and Mg ions on MSC osteogenesis in the surface modification of microrough Ti implants ????Int J Nanomedicine http://www.kidney.de/pget.php?&tw=1&pmid=31413570 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=31413570 #FOAvip English Wikipedia <ref>{{Cite pmid|31413570}}</ref> The relative effects of Ca and Mg ions on MSC osteogenesis in the surface modification of microrough Ti implants #MMPMID31413570 Park JW; Hanawa T; Chung JH Int J Nanomedicine 2019[]; 14 (?): 5697-5711 PMID31413570show ga PURPOSE: Calcium (Ca) and magnesium (Mg) ions have been used as promising bioactive ions in the surface chemistry modification of titanium (Ti) bone implants to increase bone regeneration capacity. However, it is not clear which (Ca or Mg) plays the more important role in the early osteogenic differentiation of mesenchymal stem cells (MSCs) when applied to the surface of commercially available microstructured Ti implants. This study investigated the relative effect of these two ions on the early osteogenic functionality of primary mouse bone marrow MSCs in order to obtain insights into the surface design of Ti implants with enhanced early osteogenic capacity. METHODS AND RESULTS: Wet chemical treatment was performed to modify a microrough Ti implant surface using Ca or Mg ions. Both the Ca and Mg-incorporated surfaces accelerated early cellular events and the subsequent osteogenic differentiation of MSCs compared with an unmodified microrough Ti surface. Surface Mg modification exhibited a more potent osteoblast differentiation-promoting effect than the Ca modification. Surface Mg incorporation markedly inhibited the phosphorylation of beta-catenin. CONCLUSION: These results indicate that alteration of the surface chemistry of microstructured Ti implants by wet chemical treatment with Mg ions exerts a more effect on promoting the early osteogenic differentiation of MSCs than Ca ions by enhancing early cellular functions, including focal adhesion development and stabilization of intracellular beta-catenin. |*Prostheses and Implants[MESH] |Animals[MESH] |Calcium/*pharmacology[MESH] |Cations, Divalent/pharmacology[MESH] |Cell Adhesion/drug effects[MESH] |Cell Differentiation/drug effects[MESH] |Cell Proliferation/drug effects[MESH] |Cell Shape/drug effects[MESH] |Focal Adhesions/drug effects[MESH] |Ions[MESH] |Magnesium/*pharmacology[MESH] |Mesenchymal Stem Cells/*cytology/drug effects/ultrastructure[MESH] |Mice[MESH] |Osteogenesis/*drug effects[MESH] |Phosphorylation/drug effects[MESH] |RNA, Messenger/genetics/metabolism[MESH] |Surface Properties[MESH] |Titanium/*pharmacology[MESH] |Water/chemistry[MESH] |X-Ray Diffraction[MESH]The relative effects of Ca and Mg ions on MSC osteogenesis in the surf(epmc).pdf DeepDyve Pubget Overpricing