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10.1016/j.acra.2019.07.009 http://scihub22266oqcxt.onion/10.1016/j.acra.2019.07.009 31412984!ä!31412984 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Acad+Radiol 2020 ; 27 (5): e109-e115 Nephropedia Template TP {{tp|p=31412984|t=2020. Magnetic Resonance Elastography of the Liver in Children and Adolescents: Assessment of Regional Variations in Stiffness |pdf=|usr=}}{{31412984}} gab.com Text Magnetic Resonance Elastography of the Liver in Children and Adolescents: Assessment of Regional Variations in Stiffness JO: Acad Radiol http://www.kidney.de/pget.php?&tw=1&pmid=31412984 #FOAvip RATIONALE AND OBJECTIVES: We describe our experience in measuring parenchyma stiffness across the liver Couinaud segments in lieu of the conventional practice of using a single slice-wise "global" region-of-interest. We hypothesize that the heterogeneous nature of fibrosis can lead to regional stiffness within the organ, and that it can be reflected by Couinaud segment-based magnetic resonance elastography measurements. MATERIALS AND METHODS: This retrospective study involved from 173 patients (116 males, 57 females, 1.0-22.5 years, 14.7 +/- 3.5 years) who underwent exams between June 2017 and September 2018. Liver stiffness across the eight Couinaud segments was measured in addition to a single-slice global measurement by two analysts. Inter- and intrarater analysis was performed in a subset of 20 cases. Individual segment stiffness values, the average across the segments, and the coefficients of variation (CoV) were compared to global single-slice-derived values using linear and Lin's concordance correlation coefficients. Linear correlations between stiffness values versus age, gender, and body-mass-index (BMI) were also evaluated. RESULTS: We observed CoVs ranging from 3.1%-79.2%, 17.2 +/- 7.2%. The CoV was not correlated with age or BMI (r(2) < 0.01, p?=?0.99 for both). The CoV did not differ between males (17.1 +/- 5.6%) and females (17.3 +/- 9.8%) (p = 0.88). There were no correlations between global stiffness versus age (r(2)?=?0.02, p = 0.84) or BMI (r(2)?=?0.03, p = 0.68). A range of 0.58-0.86 was observed for Lin's concordance correlation coefficient between segmental stiffness, the average stiffness across segments, and global stiffness. Segments II and VII had the highest frequency of being the stiffest Couinaud segment. The average stiffness across the segments correlated strongly with the single-slice global measurement (r(2)?=?0.88, p< 0.01). CONCLUSION: There exists potential variations in parenchyma stiffness across the liver Couinaud segments, which may reflect the heterogeneous nature of fibrosis. This variation can potentially provide additional diagnostic and clinical information. Twit Text FOAVip Magnetic Resonance Elastography of the Liver in Children and Adolescents: Assessment of Regional Variations in Stiffness ????Acad Radiol http://www.kidney.de/pget.php?&tw=1&pmid=31412984 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=31412984 #FOAvip English Wikipedia <ref>{{Cite pmid|31412984}}</ref> Magnetic Resonance Elastography of the Liver in Children and Adolescents: Assessment of Regional Variations in Stiffness #MMPMID31412984 Krishnamurthy R; Thompson BL; Shankar A; Gariepy CE; Potter CJ; Fung BR; Hu HH Acad Radiol 2020[May]; 27 (5): e109-e115 PMID31412984show ga RATIONALE AND OBJECTIVES: We describe our experience in measuring parenchyma stiffness across the liver Couinaud segments in lieu of the conventional practice of using a single slice-wise "global" region-of-interest. We hypothesize that the heterogeneous nature of fibrosis can lead to regional stiffness within the organ, and that it can be reflected by Couinaud segment-based magnetic resonance elastography measurements. MATERIALS AND METHODS: This retrospective study involved from 173 patients (116 males, 57 females, 1.0-22.5 years, 14.7 +/- 3.5 years) who underwent exams between June 2017 and September 2018. Liver stiffness across the eight Couinaud segments was measured in addition to a single-slice global measurement by two analysts. Inter- and intrarater analysis was performed in a subset of 20 cases. Individual segment stiffness values, the average across the segments, and the coefficients of variation (CoV) were compared to global single-slice-derived values using linear and Lin's concordance correlation coefficients. Linear correlations between stiffness values versus age, gender, and body-mass-index (BMI) were also evaluated. RESULTS: We observed CoVs ranging from 3.1%-79.2%, 17.2 +/- 7.2%. The CoV was not correlated with age or BMI (r(2) < 0.01, p?=?0.99 for both). The CoV did not differ between males (17.1 +/- 5.6%) and females (17.3 +/- 9.8%) (p = 0.88). There were no correlations between global stiffness versus age (r(2)?=?0.02, p = 0.84) or BMI (r(2)?=?0.03, p = 0.68). A range of 0.58-0.86 was observed for Lin's concordance correlation coefficient between segmental stiffness, the average stiffness across segments, and global stiffness. Segments II and VII had the highest frequency of being the stiffest Couinaud segment. The average stiffness across the segments correlated strongly with the single-slice global measurement (r(2)?=?0.88, p< 0.01). CONCLUSION: There exists potential variations in parenchyma stiffness across the liver Couinaud segments, which may reflect the heterogeneous nature of fibrosis. This variation can potentially provide additional diagnostic and clinical information. |Adolescent[MESH] |Adult[MESH] |Body Mass Index[MESH] |Child[MESH] |Child, Preschool[MESH] |Elasticity Imaging Techniques/*methods[MESH] |Female[MESH] |Humans[MESH] |Infant[MESH] |Liver Cirrhosis/*diagnostic imaging[MESH] |Liver/diagnostic imaging[MESH] |Magnetic Resonance Imaging/*methods[MESH] |Male[MESH] |Retrospective Studies[MESH]Magnetic Resonance Elastography of the Liver in Children and Adolescen(epmc).pdf DeepDyve Pubget Overpricing