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10.1080/02770903.2019.1652639

http://scihub22266oqcxt.onion/10.1080/02770903.2019.1652639
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31411907!ä!31411907

suck abstract from ncbi


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pmid31411907      J+Asthma 2020 ; 57 (12): 1280-1287
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  • Weighing in on asthma: Insights on BMI, magnesium, and hospitalizations from the Ohio Pediatric Asthma Repository #MMPMID31411907
  • Schuler CL; Biagini Myers JM; Kercsmar CM; Pilipenko VV; Kroner JW; Simmons JM; Austin SR; Gunkelman SM; Ross KR; McCoy KS; Kalra M; Ruddy JR; Martin LJ; Khurana Hershey GK
  • J Asthma 2020[Dec]; 57 (12): 1280-1287 PMID31411907show ga
  • Objective: Little is known about weight status and its effects on clinical course during hospitalization for asthma exacerbation. We sought to evaluate associations between weight status, specifically body mass index (BMI), with inpatient clinical course and clinical history.Methods: We retrospectively analyzed data from 2012 to 2013 on children hospitalized for asthma exacerbation in a state-wide longitudinal cohort, the Ohio Pediatric Asthma Repository. We examined BMI continuously (z scores) and categorically, comparing overweight and obese (Ov/Ob) to non-overweight and non-obese (nOv/nOb) children. We used linear mixed models controlling for site effects to determine if BMI was related to length of stay, as determined by physiologic readiness for discharge (PRD), defined as time to albuterol spaced every 4 h, need for nonstandard care or clinical history.Results: Across six hospitals, 874 children were included in analyses. BMI was positively associated with PRD (p=.008) but this increase was unlikely to be clinically significant. Ov/Ob children were more likely than nOv/nOb to require nonstandard care with repeat magnesium dosing in intensive care after dosing in the emergency department (OR = 3.23, 95%CI 1.39-7.78). Hospitalization in the year prior to enrollment was positively associated with BMI percentile (73.3 vs. 66.0, p=.028). Sleep disordered breathing was also associated with higher BMI percentile (78.2 vs. 65.9; p=.0013).Conclusions: Ov/Ob children had similar PRD to nOv/nOb children and were prone to repeat magnesium dosing. Previous hospitalization for exacerbation was positively associated with increasing BMI percentile. Additional research should investigate differential magnesium use by weight status, quantifying risks and benefits.
  • |Adolescent[MESH]
  • |Albuterol/*therapeutic use[MESH]
  • |Asthma/complications/diagnosis/*drug therapy[MESH]
  • |Body Mass Index[MESH]
  • |Child[MESH]
  • |Child, Preschool[MESH]
  • |Emergency Service, Hospital/statistics & numerical data[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Length of Stay/statistics & numerical data[MESH]
  • |Longitudinal Studies[MESH]
  • |Magnesium/*administration & dosage[MESH]
  • |Male[MESH]
  • |Obesity/complications/diagnosis/*epidemiology[MESH]
  • |Ohio/epidemiology[MESH]
  • |Overweight/complications/diagnosis/*epidemiology[MESH]
  • |Patient Discharge/statistics & numerical data[MESH]
  • |Prospective Studies[MESH]
  • |Registries/statistics & numerical data[MESH]
  • |Retrospective Studies[MESH]
  • |Risk Factors[MESH]
  • |Severity of Illness Index[MESH]
  • |Symptom Flare Up[MESH]
  • |Time Factors[MESH]


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