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10.1111/imm.13102 http://scihub22266oqcxt.onion/10.1111/imm.13102 31393598!6797864!31393598     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Immunology 2019 ; 158 (3): 206-218 Nephropedia Template TP {{tp|p=31393598|t=2019. The role of CCR1 and therapeutic effects of anti-CCL3 antibody in herpes simplex virus-induced Behcet s disease mouse model |pdf=|usr=}}{{31393598}} gab.com Text The role of CCR1 and therapeutic effects of anti-CCL3 antibody in herpes simplex virus-induced Behcet s disease mouse model JO: Immunology http://www.kidney.de/pget.php?&tw=1&pmid=31393598 #FOAvip Behcet's disease (BD) is a chronic systemic inflammatory disease with unclear etiopathogenesis. Although gene variants of CC chemokine receptor type 1 (CCR1) have been reported, the protein expression of CCR1 in patients with BD remains unclear. The objective of this study was to analyze the frequencies of CCR1(+) cells in a herpes simplex virus-induced mouse model of BD. The frequencies of CCR1(+) cells on the surface and in the cytoplasm of peripheral blood mononuclear cells and lymph nodes were analyzed by flow cytometry. The CCR1(+) cells were significantly down-regulated in BD mice compared with the normal control and symptom-free control mice. Colchicine and pentoxifylline treatment improved the symptoms of BD and increased the frequencies of CCR1(+) cells in BD mice. Treatment with chemokine CC motif ligand 3 (CCL3), a ligand of CCR1, caused BD symptoms to deteriorate in 10 of 16 BD mice (62.5%) via down-regulation of CCR1(+) cells. Anti-CCL3 antibody treatment ameliorated BD symptoms in 10 of 20 mice (50%) and significantly decreased the disease severity score compared with CCL3-treated BD mice (P = 0.01) via up-regulation of CCR1(+) cell frequencies. In patients with BD, plasma levels of CCL3 in an active state were significantly higher than in healthy control individuals (P = 0.02). These results show that the up-regulation of CCR1(+) cells was related to the control of systemic inflammation of BD in mouse models. Twit Text FOAVip The role of CCR1 and therapeutic effects of anti-CCL3 antibody in herpes simplex virus-induced Behcet s disease mouse model ????Immunology http://www.kidney.de/pget.php?&tw=1&pmid=31393598 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=31393598 #FOAvip English Wikipedia <ref>{{Cite pmid|31393598}}</ref> The role of CCR1 and therapeutic effects of anti-CCL3 antibody in herpes simplex virus-induced Behcet s disease mouse model #MMPMID31393598 Sayeed HM; Lee ES; Byun HO; Sohn S Immunology 2019[Nov]; 158 (3): 206-218 PMID31393598show ga Behcet's disease (BD) is a chronic systemic inflammatory disease with unclear etiopathogenesis. Although gene variants of CC chemokine receptor type 1 (CCR1) have been reported, the protein expression of CCR1 in patients with BD remains unclear. The objective of this study was to analyze the frequencies of CCR1(+) cells in a herpes simplex virus-induced mouse model of BD. The frequencies of CCR1(+) cells on the surface and in the cytoplasm of peripheral blood mononuclear cells and lymph nodes were analyzed by flow cytometry. The CCR1(+) cells were significantly down-regulated in BD mice compared with the normal control and symptom-free control mice. Colchicine and pentoxifylline treatment improved the symptoms of BD and increased the frequencies of CCR1(+) cells in BD mice. Treatment with chemokine CC motif ligand 3 (CCL3), a ligand of CCR1, caused BD symptoms to deteriorate in 10 of 16 BD mice (62.5%) via down-regulation of CCR1(+) cells. Anti-CCL3 antibody treatment ameliorated BD symptoms in 10 of 20 mice (50%) and significantly decreased the disease severity score compared with CCL3-treated BD mice (P = 0.01) via up-regulation of CCR1(+) cell frequencies. In patients with BD, plasma levels of CCL3 in an active state were significantly higher than in healthy control individuals (P = 0.02). These results show that the up-regulation of CCR1(+) cells was related to the control of systemic inflammation of BD in mouse models. |Animals[MESH] |Antibodies/*pharmacology[MESH] |Behcet Syndrome/*drug therapy/immunology/pathology/virology[MESH] |Chemokine CCL3/*antagonists & inhibitors/immunology[MESH] |Disease Models, Animal[MESH] |Herpes Simplex/*drug therapy/immunology/pathology[MESH] |Humans[MESH] |Leukocytes, Mononuclear/*immunology/pathology[MESH] |Male[MESH] |Mice[MESH] |Mice, Inbred ICR[MESH] |Receptors, CCR1/*immunology[MESH]The role of CCR1 and therapeutic effects of anti-CCL3 antibody in herp(epmc).pdf DeepDyve Pubget Overpricing