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10.1016/j.intimp.2019.105774 http://scihub22266oqcxt.onion/10.1016/j.intimp.2019.105774 31351363!ä!31351363 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Int+Immunopharmacol 2019 ; 75 (ä): 105774 Nephropedia Template TP {{tp|p=31351363|t=2019. Ameliorative effect of Magnesium Isoglycyrrhizinate on hepatic encephalopathy by Epirubicin |pdf=|usr=}}{{31351363}} gab.com Text Ameliorative effect of Magnesium Isoglycyrrhizinate on hepatic encephalopathy by Epirubicin JO: Int Immunopharmacol http://www.kidney.de/pget.php?&tw=1&pmid=31351363 #FOAvip BACKGROUND: The purpose of the present study was to evaluate the protective effect of Magnesium Isoglycyrrhizinate (MI) on Epirubicin (EPI)-induced hepatic encephalopathy (HE) and explore its underlying mechanism. METHODS: Mice were divided randomly into groups for treatments as follows: control group, EPI group (Model group), EPI?+?MI (25, 50?mg/kg) group. Morris water maze test were conducted to evaluate the spatial learning and memory ability. The serum and hippocampus levels of oxidative stress or inflammation were uncovered with the detection of superoxide dismutase (SOD), malondialdehyde (MDA), and pro-inflammatory cytokines (IL-1beta, IL-6, TNF-alpha). RESULTS: As a result, treatment with MI effectively ameliorated the EPI-induced decline in the ability of spatial learning and memory. MI also significantly relieved the severity of oxidative stress or inflammation in serum and hippocampus, which was accompanied with regulating liver functional parameters. Western blot data demonstrated that administration of MI could regulate the redox-related expressions of Txnip, Trx, Nrf2, HO-1, p-IkappaB-alpha, p-NF-kappaB, Caspase-3, Caspase-9, Bax and Bcl-2 in EPI-stimulated hepatic encephalopathy (HE). And the potency of MI treatments on Nrf2, NF-kappaB expression was also confirmed with immunohistochemical analysis. CONCLUSIONS: Taken together, the protective effect of Magnesium Isoglycyrrhizinate on EPI-induced hepatic encephalopathy might be mediated via the Txnip/Nrf2/NF-kappaB signaling pathway. Twit Text FOAVip Ameliorative effect of Magnesium Isoglycyrrhizinate on hepatic encephalopathy by Epirubicin ????Int Immunopharmacol http://www.kidney.de/pget.php?&tw=1&pmid=31351363 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=31351363 #FOAvip English Wikipedia <ref>{{Cite pmid|31351363}}</ref> Ameliorative effect of Magnesium Isoglycyrrhizinate on hepatic encephalopathy by Epirubicin #MMPMID31351363 Jiang W; Guo H; Su D; Xu H; Gu H; Hao K Int Immunopharmacol 2019[Oct]; 75 (ä): 105774 PMID31351363show ga BACKGROUND: The purpose of the present study was to evaluate the protective effect of Magnesium Isoglycyrrhizinate (MI) on Epirubicin (EPI)-induced hepatic encephalopathy (HE) and explore its underlying mechanism. METHODS: Mice were divided randomly into groups for treatments as follows: control group, EPI group (Model group), EPI?+?MI (25, 50?mg/kg) group. Morris water maze test were conducted to evaluate the spatial learning and memory ability. The serum and hippocampus levels of oxidative stress or inflammation were uncovered with the detection of superoxide dismutase (SOD), malondialdehyde (MDA), and pro-inflammatory cytokines (IL-1beta, IL-6, TNF-alpha). RESULTS: As a result, treatment with MI effectively ameliorated the EPI-induced decline in the ability of spatial learning and memory. MI also significantly relieved the severity of oxidative stress or inflammation in serum and hippocampus, which was accompanied with regulating liver functional parameters. Western blot data demonstrated that administration of MI could regulate the redox-related expressions of Txnip, Trx, Nrf2, HO-1, p-IkappaB-alpha, p-NF-kappaB, Caspase-3, Caspase-9, Bax and Bcl-2 in EPI-stimulated hepatic encephalopathy (HE). And the potency of MI treatments on Nrf2, NF-kappaB expression was also confirmed with immunohistochemical analysis. CONCLUSIONS: Taken together, the protective effect of Magnesium Isoglycyrrhizinate on EPI-induced hepatic encephalopathy might be mediated via the Txnip/Nrf2/NF-kappaB signaling pathway. |Animals[MESH] |Antibiotics, Antineoplastic/*adverse effects[MESH] |Carrier Proteins/immunology[MESH] |Cognitive Dysfunction/chemically induced/drug therapy/immunology[MESH] |Cytokines/blood/immunology[MESH] |Epirubicin/*adverse effects[MESH] |Hepatic Encephalopathy/chemically induced/*drug therapy/immunology[MESH] |Hippocampus/drug effects/immunology[MESH] |Male[MESH] |Malondialdehyde/blood/immunology[MESH] |Memory/drug effects[MESH] |Mice, Inbred BALB C[MESH] |NF-E2-Related Factor 2/immunology[MESH] |NF-kappa B/immunology[MESH] |Neuroprotective Agents/pharmacology/*therapeutic use[MESH] |Saponins/pharmacology/*therapeutic use[MESH] |Spatial Learning/drug effects[MESH] |Superoxide Dismutase/blood/immunology[MESH] |Thioredoxins/immunology[MESH]Ameliorative effect of Magnesium Isoglycyrrhizinate on hepatic encepha(epmc).pdf DeepDyve Pubget Overpricing