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10.1007/s00401-019-02047-3 http://scihub22266oqcxt.onion/10.1007/s00401-019-02047-3 31346692!6778062!31346692     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Acta+Neuropathol 2019 ; 138 (4): 653-665 Nephropedia Template TP {{tp|p=31346692|t=2019. The neuropathology of fatal encephalomyelitis in human Borna virus infection |pdf=|usr=}}{{31346692}} gab.com Text The neuropathology of fatal encephalomyelitis in human Borna virus infection JO: Acta Neuropathol http://www.kidney.de/pget.php?&tw=1&pmid=31346692 #FOAvip After many years of controversy, there is now recent and solid evidence that classical Borna disease virus 1 (BoDV-1) can infect humans. On the basis of six brain autopsies, we provide the first systematic overview on BoDV-1 tissue distribution and the lesion pattern in fatal BoDV-1-induced encephalitis. All brains revealed a non-purulent, lymphocytic sclerosing panencephalomyelitis with detection of BoDV-1-typical eosinophilic, spherical intranuclear Joest-Degen inclusion bodies. While the composition of histopathological changes was constant, the inflammatory distribution pattern varied interindividually, affecting predominantly the basal nuclei in two patients, hippocampus in one patient, whereas two patients showed a more diffuse distribution. By immunohistochemistry and RNA in situ hybridization, BoDV-1 was detected in all examined brain tissue samples. Furthermore, infection of the peripheral nervous system was observed. This study aims at raising awareness to human bornavirus encephalitis as differential diagnosis in lymphocytic sclerosing panencephalomyelitis. A higher attention to human BoDV-1 infection by health professionals may likely increase the detection of more cases and foster a clearer picture of the disease. Twit Text FOAVip The neuropathology of fatal encephalomyelitis in human Borna virus infection ????Acta Neuropathol http://www.kidney.de/pget.php?&tw=1&pmid=31346692 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=31346692 #FOAvip English Wikipedia <ref>{{Cite pmid|31346692}}</ref> The neuropathology of fatal encephalomyelitis in human Borna virus infection #MMPMID31346692 Liesche F; Ruf V; Zoubaa S; Kaletka G; Rosati M; Rubbenstroth D; Herden C; Goehring L; Wunderlich S; Wachter MF; Rieder G; Lichtmannegger I; Permanetter W; Heckmann JG; Angstwurm K; Neumann B; Markl B; Haschka S; Niller HH; Schmidt B; Jantsch J; Brochhausen C; Schlottau K; Ebinger A; Hemmer B; Riemenschneider MJ; Herms J; Beer M; Matiasek K; Schlegel J Acta Neuropathol 2019[Oct]; 138 (4): 653-665 PMID31346692show ga After many years of controversy, there is now recent and solid evidence that classical Borna disease virus 1 (BoDV-1) can infect humans. On the basis of six brain autopsies, we provide the first systematic overview on BoDV-1 tissue distribution and the lesion pattern in fatal BoDV-1-induced encephalitis. All brains revealed a non-purulent, lymphocytic sclerosing panencephalomyelitis with detection of BoDV-1-typical eosinophilic, spherical intranuclear Joest-Degen inclusion bodies. While the composition of histopathological changes was constant, the inflammatory distribution pattern varied interindividually, affecting predominantly the basal nuclei in two patients, hippocampus in one patient, whereas two patients showed a more diffuse distribution. By immunohistochemistry and RNA in situ hybridization, BoDV-1 was detected in all examined brain tissue samples. Furthermore, infection of the peripheral nervous system was observed. This study aims at raising awareness to human bornavirus encephalitis as differential diagnosis in lymphocytic sclerosing panencephalomyelitis. A higher attention to human BoDV-1 infection by health professionals may likely increase the detection of more cases and foster a clearer picture of the disease. |*Borna disease virus[MESH] |Adolescent[MESH] |Aged[MESH] |Borna Disease/*pathology[MESH] |Brain/*pathology[MESH] |Encephalomyelitis/*pathology[MESH] |Female[MESH] |Humans[MESH] |Middle Aged[MESH] |Retrospective Studies[MESH]The neuropathology of fatal encephalomyelitis in human Borna virus inf(epmc).pdf DeepDyve Pubget Overpricing