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10.1158/2326-6066.CIR-18-0489 http://scihub22266oqcxt.onion/10.1158/2326-6066.CIR-18-0489 31340983!6726548!31340983     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=31340983&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Cancer+Immunol+Res 2019 ; 7 (9): 1497-1510 Nephropedia Template TP {{tp|p=31340983|t=2019. Immune-Checkpoint Protein VISTA Regulates Antitumor Immunity by Controlling Myeloid Cell-Mediated Inflammation and Immunosuppression |pdf=|usr=}}{{31340983}} gab.com Text Immune-Checkpoint Protein VISTA Regulates Antitumor Immunity by Controlling Myeloid Cell-Mediated Inflammation and Immunosuppression JO: Cancer Immunol Res http://www.kidney.de/pget.php?&tw=1&pmid=31340983 #FOAvip Immune-checkpoint protein V-domain immunoglobulin suppressor of T-cell activation (VISTA) controls antitumor immunity and is a valuable target for cancer immunotherapy. This study identified a role of VISTA in regulating Toll-like receptor (TLR) signaling in myeloid cells and controlling myeloid cell-mediated inflammation and immunosuppression. VISTA modulated the polyubiquitination and protein expression of TRAF6. Consequently, VISTA dampened TLR-mediated activation of MAPK/AP-1 and IKK/NF-kappaB signaling cascades. At cellular levels, VISTA regulated the effector functions of myeloid-derived suppressor cells and tolerogenic dendritic cell (DC) subsets. Blocking VISTA augmented their ability to produce proinflammatory mediators and diminished their T cell-suppressive functions. These myeloid cell-dependent effects resulted in a stimulatory tumor microenvironment that promoted T-cell infiltration and activation. We conclude that VISTA is a critical myeloid cell-intrinsic immune-checkpoint protein and that the reprogramming of tolerogenic myeloid cells following VISTA blockade promotes the development of T cell-mediated antitumor immunity. Twit Text FOAVip Immune-Checkpoint Protein VISTA Regulates Antitumor Immunity by Controlling Myeloid Cell-Mediated Inflammation and Immunosuppression ????Cancer Immunol Res http://www.kidney.de/pget.php?&tw=1&pmid=31340983 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=31340983 #FOAvip English Wikipedia <ref>{{Cite pmid|31340983}}</ref> Immune-Checkpoint Protein VISTA Regulates Antitumor Immunity by Controlling Myeloid Cell-Mediated Inflammation and Immunosuppression #MMPMID31340983 Xu W; Dong J; Zheng Y; Zhou J; Yuan Y; Ta HM; Miller HE; Olson M; Rajasekaran K; Ernstoff MS; Wang D; Malarkannan S; Wang L Cancer Immunol Res 2019[Sep]; 7 (9): 1497-1510 PMID31340983show ga Immune-checkpoint protein V-domain immunoglobulin suppressor of T-cell activation (VISTA) controls antitumor immunity and is a valuable target for cancer immunotherapy. This study identified a role of VISTA in regulating Toll-like receptor (TLR) signaling in myeloid cells and controlling myeloid cell-mediated inflammation and immunosuppression. VISTA modulated the polyubiquitination and protein expression of TRAF6. Consequently, VISTA dampened TLR-mediated activation of MAPK/AP-1 and IKK/NF-kappaB signaling cascades. At cellular levels, VISTA regulated the effector functions of myeloid-derived suppressor cells and tolerogenic dendritic cell (DC) subsets. Blocking VISTA augmented their ability to produce proinflammatory mediators and diminished their T cell-suppressive functions. These myeloid cell-dependent effects resulted in a stimulatory tumor microenvironment that promoted T-cell infiltration and activation. We conclude that VISTA is a critical myeloid cell-intrinsic immune-checkpoint protein and that the reprogramming of tolerogenic myeloid cells following VISTA blockade promotes the development of T cell-mediated antitumor immunity. |*Immunomodulation[MESH] |Animals[MESH] |B7 Antigens/genetics/*metabolism[MESH] |Cytokines/biosynthesis[MESH] |Disease Models, Animal[MESH] |Extracellular Signal-Regulated MAP Kinases[MESH] |Humans[MESH] |Immune Tolerance[MESH] |Immunosuppression Therapy[MESH] |Inflammation Mediators/metabolism[MESH] |Inflammation/*etiology/metabolism[MESH] |Intracellular Signaling Peptides and Proteins/metabolism[MESH] |Melanoma, Experimental[MESH] |Mice[MESH] |Mice, Knockout[MESH] |Myeloid Cells/*immunology/*metabolism[MESH] |Myeloid-Derived Suppressor Cells/immunology/metabolism[MESH] |NF-kappa B/metabolism[MESH] |Neoplasms/*immunology/*metabolism[MESH] |Signal Transduction[MESH] |Toll-Like Receptors/metabolism[MESH]Immune-Checkpoint Protein VISTA Regulates Antitumor Immunity by Contro(epmc).pdf DeepDyve Pubget Overpricing