Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.3390/ijms20143439 http://scihub22266oqcxt.onion/10.3390/ijms20143439 31336935!6678825!31336935     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Int+J+Mol+Sci 2019 ; 20 (14): ä Nephropedia Template TP {{tp|p=31336935|t=2019. Magnesium Is a Key Player in Neuronal Maturation and Neuropathology |pdf=|usr=}}{{31336935}} gab.com Text Magnesium Is a Key Player in Neuronal Maturation and Neuropathology JO: Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=31336935 #FOAvip Magnesium (Mg) is the second most abundant cation in mammalian cells, and it is essential for numerous cellular processes including enzymatic reactions, ion channel functions, metabolic cycles, cellular signaling, and DNA/RNA stabilities. Because of the versatile and universal nature of Mg(2+), the homeostasis of intracellular Mg(2+) is physiologically linked to growth, proliferation, differentiation, energy metabolism, and death of cells. On the cellular and tissue levels, maintaining Mg(2+) within optimal levels according to the biological context, such as cell types, developmental stages, extracellular environments, and pathophysiological conditions, is crucial for development, normal functions, and diseases. Hence, Mg(2+) is pathologically involved in cancers, diabetes, and neurodegenerative diseases, such as Parkinson's disease, Alzheimer's disease, and demyelination. In the research field regarding the roles and mechanisms of Mg(2+) regulation, numerous controversies caused by its versatility and complexity still exist. As Mg(2+), at least, plays critical roles in neuronal development, healthy normal functions, and diseases, appropriate Mg(2+) supplementation exhibits neurotrophic effects in a majority of cases. Hence, the control of Mg(2+) homeostasis can be a candidate for therapeutic targets in neuronal diseases. In this review, recent results regarding the roles of intracellular Mg(2+) and its regulatory system in determining the cell phenotype, fate, and diseases in the nervous system are summarized, and an overview of the comprehensive roles of Mg(2+) is provided. Twit Text FOAVip Magnesium Is a Key Player in Neuronal Maturation and Neuropathology ????Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=31336935 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=31336935 #FOAvip English Wikipedia <ref>{{Cite pmid|31336935}}</ref> Magnesium Is a Key Player in Neuronal Maturation and Neuropathology #MMPMID31336935 Yamanaka R; Shindo Y; Oka K Int J Mol Sci 2019[Jul]; 20 (14): ä PMID31336935show ga Magnesium (Mg) is the second most abundant cation in mammalian cells, and it is essential for numerous cellular processes including enzymatic reactions, ion channel functions, metabolic cycles, cellular signaling, and DNA/RNA stabilities. Because of the versatile and universal nature of Mg(2+), the homeostasis of intracellular Mg(2+) is physiologically linked to growth, proliferation, differentiation, energy metabolism, and death of cells. On the cellular and tissue levels, maintaining Mg(2+) within optimal levels according to the biological context, such as cell types, developmental stages, extracellular environments, and pathophysiological conditions, is crucial for development, normal functions, and diseases. Hence, Mg(2+) is pathologically involved in cancers, diabetes, and neurodegenerative diseases, such as Parkinson's disease, Alzheimer's disease, and demyelination. In the research field regarding the roles and mechanisms of Mg(2+) regulation, numerous controversies caused by its versatility and complexity still exist. As Mg(2+), at least, plays critical roles in neuronal development, healthy normal functions, and diseases, appropriate Mg(2+) supplementation exhibits neurotrophic effects in a majority of cases. Hence, the control of Mg(2+) homeostasis can be a candidate for therapeutic targets in neuronal diseases. In this review, recent results regarding the roles of intracellular Mg(2+) and its regulatory system in determining the cell phenotype, fate, and diseases in the nervous system are summarized, and an overview of the comprehensive roles of Mg(2+) is provided. |*Cell Differentiation[MESH] |*Disease Susceptibility[MESH] |Animals[MESH] |Brain/metabolism[MESH] |Energy Metabolism[MESH] |Genomic Instability[MESH] |Homeostasis[MESH] |Humans[MESH] |Intracellular Space/metabolism[MESH] |Magnesium/*metabolism[MESH] |Neurogenesis[MESH] |Neurons/*cytology/*metabolism[MESH] |Reactive Oxygen Species[MESH]Magnesium Is a Key Player in Neuronal Maturation and Neuropathology (epmc).pdf DeepDyve Pubget Overpricing