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10.1002/cti2.1067 http://scihub22266oqcxt.onion/10.1002/cti2.1067 31312450!6613463!31312450     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Clin+Transl+Immunology 2019 ; 8 (7): e1067 Nephropedia Template TP {{tp|p=31312450|t=2019. Harnessing host-virus evolution in antiviral therapy and immunotherapy |pdf=|usr=}}{{31312450}} gab.com Text Harnessing host-virus evolution in antiviral therapy and immunotherapy JO: Clin Transl Immunology http://www.kidney.de/pget.php?&tw=1&pmid=31312450 #FOAvip Pathogen resistance and development costs are major challenges in current approaches to antiviral therapy. The high error rate of RNA synthesis and reverse-transcription confers genome plasticity, enabling the remarkable adaptability of RNA viruses to antiviral intervention. However, this property is coupled to fundamental constraints including limits on the size of information available to manipulate complex hosts into supporting viral replication. Accordingly, RNA viruses employ various means to extract maximum utility from their informationally limited genomes that, correspondingly, may be leveraged for effective host-oriented therapies. Host-oriented approaches are becoming increasingly feasible because of increased availability of bioactive compounds and recent advances in immunotherapy and precision medicine, particularly genome editing, targeted delivery methods and RNAi. In turn, one driving force behind these innovations is the increasingly detailed understanding of evolutionarily diverse host-virus interactions, which is the key concern of an emerging field, neo-virology. This review examines biotechnological solutions to disease and other sustainability issues of our time that leverage the properties of RNA and DNA viruses as developed through co-evolution with their hosts. Twit Text FOAVip Harnessing host-virus evolution in antiviral therapy and immunotherapy ????Clin Transl Immunology http://www.kidney.de/pget.php?&tw=1&pmid=31312450 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=31312450 #FOAvip English Wikipedia <ref>{{Cite pmid|31312450}}</ref> Harnessing host-virus evolution in antiviral therapy and immunotherapy #MMPMID31312450 Heaton SM Clin Transl Immunology 2019[]; 8 (7): e1067 PMID31312450show ga Pathogen resistance and development costs are major challenges in current approaches to antiviral therapy. The high error rate of RNA synthesis and reverse-transcription confers genome plasticity, enabling the remarkable adaptability of RNA viruses to antiviral intervention. However, this property is coupled to fundamental constraints including limits on the size of information available to manipulate complex hosts into supporting viral replication. Accordingly, RNA viruses employ various means to extract maximum utility from their informationally limited genomes that, correspondingly, may be leveraged for effective host-oriented therapies. Host-oriented approaches are becoming increasingly feasible because of increased availability of bioactive compounds and recent advances in immunotherapy and precision medicine, particularly genome editing, targeted delivery methods and RNAi. In turn, one driving force behind these innovations is the increasingly detailed understanding of evolutionarily diverse host-virus interactions, which is the key concern of an emerging field, neo-virology. This review examines biotechnological solutions to disease and other sustainability issues of our time that leverage the properties of RNA and DNA viruses as developed through co-evolution with their hosts. äHarnessing host-virus evolution in antiviral therapy and immunotherapy(epmc).pdf DeepDyve Pubget Overpricing