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10.1186/s40478-019-0754-y http://scihub22266oqcxt.onion/10.1186/s40478-019-0754-y 31277708/?report=reader!6612163!31277708     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Acta+Neuropathol+Commun 2019 ; 7 (1): 109 Nephropedia Template TP {{tp|p=31277708|t=2019. Intersection of pathological tau and microglia at the synapse |pdf=|usr=}}{{31277708}} gab.com Text Intersection of pathological tau and microglia at the synapse JO: Acta Neuropathol Commun http://www.kidney.de/pget.php?&tw=1&pmid=31277708 #FOAvip Tauopathies are a heterogenous class of diseases characterized by cellular accumulation of aggregated tau and include diseases such as Alzheimer's disease (AD), progressive supranuclear palsy and chronic traumatic encephalopathy. Tau pathology is strongly linked to neurodegeneration and clinical symptoms in tauopathy patients. Furthermore, synapse loss is an early pathological event in tauopathies and is the strongest correlate of cognitive decline. Tau pathology is additionally associated with chronic neuroinflammatory processes, such as reactive microglia, astrocytes, and increased levels of pro-inflammatory molecules (e.g. complement proteins, cytokines). Recent studies show that as the principal immune cells of the brain, microglia play a particularly important role in the initiation and progression of tau pathology and associated neurodegeneration. Furthermore, AD risk genes such as Triggering receptor expressed on myeloid cells 2 (TREM2) and Apolipoprotein E (APOE) are enriched in the innate immune system and modulate the neuroinflammatory response of microglia to tau pathology. Microglia can play an active role in synaptic dysfunction by abnormally phagocytosing synaptic compartments of neurons with tau pathology. Furthermore, microglia are involved in synaptic spreading of tau - a process which is thought to underlie the progressive nature of tau pathology propagation through the brain. Spreading of pathological tau is also the predominant target for tau-based immunotherapy. Active tau vaccines, therapeutic tau antibodies and other approaches targeting the immune system are actively explored as treatment options for AD and other tauopathies. This review describes the role of microglia in the pathobiology of tauopathies and the mechanism of action of potential therapeutics targeting the immune system in tauopathies. Twit Text FOAVip Intersection of pathological tau and microglia at the synapse ????Acta Neuropathol Commun http://www.kidney.de/pget.php?&tw=1&pmid=31277708 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=31277708 #FOAvip English Wikipedia <ref>{{Cite pmid|31277708}}</ref> Intersection of pathological tau and microglia at the synapse #MMPMID31277708 Vogels T; Murgoci AN; Hromadka T Acta Neuropathol Commun 2019[Jul]; 7 (1): 109 PMID31277708show ga Tauopathies are a heterogenous class of diseases characterized by cellular accumulation of aggregated tau and include diseases such as Alzheimer's disease (AD), progressive supranuclear palsy and chronic traumatic encephalopathy. Tau pathology is strongly linked to neurodegeneration and clinical symptoms in tauopathy patients. Furthermore, synapse loss is an early pathological event in tauopathies and is the strongest correlate of cognitive decline. Tau pathology is additionally associated with chronic neuroinflammatory processes, such as reactive microglia, astrocytes, and increased levels of pro-inflammatory molecules (e.g. complement proteins, cytokines). Recent studies show that as the principal immune cells of the brain, microglia play a particularly important role in the initiation and progression of tau pathology and associated neurodegeneration. Furthermore, AD risk genes such as Triggering receptor expressed on myeloid cells 2 (TREM2) and Apolipoprotein E (APOE) are enriched in the innate immune system and modulate the neuroinflammatory response of microglia to tau pathology. Microglia can play an active role in synaptic dysfunction by abnormally phagocytosing synaptic compartments of neurons with tau pathology. Furthermore, microglia are involved in synaptic spreading of tau - a process which is thought to underlie the progressive nature of tau pathology propagation through the brain. Spreading of pathological tau is also the predominant target for tau-based immunotherapy. Active tau vaccines, therapeutic tau antibodies and other approaches targeting the immune system are actively explored as treatment options for AD and other tauopathies. This review describes the role of microglia in the pathobiology of tauopathies and the mechanism of action of potential therapeutics targeting the immune system in tauopathies. |Animals[MESH] |Apolipoproteins E/metabolism[MESH] |Humans[MESH] |Membrane Glycoproteins/metabolism[MESH] |Microglia/*metabolism/pathology[MESH] |Receptors, Immunologic/metabolism[MESH] |Synapses/*metabolism/pathology[MESH] |Tauopathies/*metabolism/pathology[MESH]Intersection of pathological tau and microglia at the synapse (epmc).pdf DeepDyve Pubget Overpricing