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10.1007/BF02556670

http://scihub22266oqcxt.onion/10.1007/BF02556670
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3124941!ä!3124941

suck abstract from ncbi


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pmid3124941      Calcif+Tissue+Int 1987 ; 41 (6): 321-5
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  • Inflammation-mediated osteopenia (IMO) during acute inflammation in rats is due to a transient inhibition of bone formation #MMPMID3124941
  • Pfeilschifter J; Wuster C; Vogel M; Enderes B; Ziegler R; Minne HW
  • Calcif Tissue Int 1987[Dec]; 41 (6): 321-5 PMID3124941show ga
  • Local inflammation was induced in rats through the subcutaneous injection of magnesium silicate. Trabecular bone volume of the tibia decreased progressively during a 3 week observation period following the inflammatory stimulus. The trabecular bone surface covered with osteoblasts was strikingly reduced during the first week but had normalized by the end of the third week. Calcification rate in the cortical bone of the tibia was reduced with a parallel reduction in endosteal osteoid seam width. Both calcification rate and tetracycline double-labeled surface of vertebral trabecular bone were reduced during the first 2 weeks. Neither total bone resorption surface nor active bone resorption surface were increased. There was a decrease in osteoclast numbers/mm2 bone tissue associated with decreasing bone volume. Our data demonstrate a transient inhibition of bone formation during acute inflammation in the rat and indicate that changes in osteoblast function are part of the acute phase response following local inflammation.
  • |*Bone Development[MESH]
  • |*Magnesium Silicates[MESH]
  • |Acute-Phase Reaction/etiology/*physiopathology[MESH]
  • |Animals[MESH]
  • |Bone Diseases, Metabolic/etiology/*physiopathology[MESH]
  • |Calcification, Physiologic[MESH]
  • |Female[MESH]
  • |Inflammation/*physiopathology[MESH]
  • |Osteoblasts/physiology[MESH]
  • |Osteoclasts/physiology[MESH]
  • |Rats[MESH]
  • |Silicic Acid/adverse effects[MESH]


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