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10.3389/fimmu.2019.01202 http://scihub22266oqcxt.onion/10.3389/fimmu.2019.01202 31231374!6558381!31231374     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=31231374&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Front+Immunol 2019 ; 10 (?): 1202 Nephropedia Template TP {{tp|p=31231374|t=2019. Increased CD14(+)HLA-DR(-/low) Myeloid-Derived Suppressor Cells Correlate With Disease Severity in Systemic Lupus Erythematosus Patients in an iNOS-Dependent Manner |pdf=|usr=}}{{31231374}} gab.com Text Increased CD14(+)HLA-DR(-/low) Myeloid-Derived Suppressor Cells Correlate With Disease Severity in Systemic Lupus Erythematosus Patients in an iNOS-Dependent Manner JO: Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=31231374 #FOAvip Myeloid-derived suppressor cells (MDSCs) comprise of a population of cells, which suppress the innate and adaptive immune system via different mechanisms. MDSCs are accumulated under pathological conditions. The present study aimed to clarify the pathological role of MDSCs in systemic lupus erythematosus (SLE) patients. Consequently, the level of circulating M-MDSCs was significantly increased in newly diagnosed SLE patients as compared to healthy controls. An elevated level of M-MDSCs was positively correlated with the disease severity in SLE patients and an immunosuppressive role was exerted in an iNOS-dependent manner. The decrease in the number of M-MDSCs after therapy rendered them as an indicator for the efficacy of treatment. These results demonstrated that M-MDSCs participated in the pathological progress in SLE patients. Thus, MDSCs are attractive biomarkers and therapeutic targets for SLE patients. Twit Text FOAVip Increased CD14(+)HLA-DR(-/low) Myeloid-Derived Suppressor Cells Correlate With Disease Severity in Systemic Lupus Erythematosus Patients in an iNOS-Dependent Manner ????Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=31231374 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=31231374 #FOAvip English Wikipedia <ref>{{Cite pmid|31231374}}</ref> Increased CD14(+)HLA-DR(-/low) Myeloid-Derived Suppressor Cells Correlate With Disease Severity in Systemic Lupus Erythematosus Patients in an iNOS-Dependent Manner #MMPMID31231374 Wang Z; Zhu F; Wang J; Tao Q; Xu X; Wang H; Xiong S; Wang Y; Zhai Z Front Immunol 2019[]; 10 (?): 1202 PMID31231374show ga Myeloid-derived suppressor cells (MDSCs) comprise of a population of cells, which suppress the innate and adaptive immune system via different mechanisms. MDSCs are accumulated under pathological conditions. The present study aimed to clarify the pathological role of MDSCs in systemic lupus erythematosus (SLE) patients. Consequently, the level of circulating M-MDSCs was significantly increased in newly diagnosed SLE patients as compared to healthy controls. An elevated level of M-MDSCs was positively correlated with the disease severity in SLE patients and an immunosuppressive role was exerted in an iNOS-dependent manner. The decrease in the number of M-MDSCs after therapy rendered them as an indicator for the efficacy of treatment. These results demonstrated that M-MDSCs participated in the pathological progress in SLE patients. Thus, MDSCs are attractive biomarkers and therapeutic targets for SLE patients. |Adolescent[MESH] |Adult[MESH] |CD4-Positive T-Lymphocytes/immunology[MESH] |HLA-DR Antigens/analysis[MESH] |Humans[MESH] |Immune Tolerance[MESH] |Interferon-gamma/biosynthesis/genetics[MESH] |Leukocytes, Mononuclear/drug effects[MESH] |Lipopolysaccharide Receptors/analysis[MESH] |Lupus Erythematosus, Systemic/blood/enzymology/*immunology[MESH] |Myeloid-Derived Suppressor Cells/chemistry/*immunology[MESH] |Nitric Oxide Synthase Type II/antagonists & inhibitors/*physiology[MESH] |Severity of Illness Index[MESH]Increased CD14(+)HLA-DR(-/low) Myeloid-Derived Suppressor Cells Correl(epmc).pdf DeepDyve Pubget Overpricing