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10.1038/s41418-019-0366-x http://scihub22266oqcxt.onion/10.1038/s41418-019-0366-x 31209359!7206066!31209359     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Death+Differ 2020 ; 27 (2): 466-481 Nephropedia Template TP {{tp|p=31209359|t=2020. Magnesium protects against sepsis by blocking gasdermin D N-terminal-induced pyroptosis |pdf=|usr=}}{{31209359}} gab.com Text Magnesium protects against sepsis by blocking gasdermin D N-terminal-induced pyroptosis JO: Cell Death Differ http://www.kidney.de/pget.php?&tw=1&pmid=31209359 #FOAvip Hypomagnesemia is a significant risk factor for critically ill patients to develop sepsis, a life-threatening disease with a mortality rate over 25%. Our clinic data analysis showed that hypomagnesemia is associated with a decreased monocyte count in septic patients. At the cellular level, we found that Mg(2+) inhibits pyroptosis. Specifically, Mg(2+) limits the oligomerization and membrane localization of gasdermin D N-terminal (GSDMD-NT) upon the activation of either the canonical or noncanonical pyroptotic pathway. Mechanistically, we demonstrated that Ca(2+) influx is a prerequisite for the function of GSDMD-NT. Mg(2+) blocks Ca(2+) influx by inhibiting the ATP-gated Ca(2+) channel P2X7, thereby impeding the function of GSDMD-NT and inhibiting lipopolysaccharide (LPS)-induced noncanonical pyroptosis. Furthermore, Mg(2+) administration protects mice from LPS-induced lethal septic shock. Together, our data reveal the underlying mechanism of how Mg(2+) inhibits pyroptosis and suggest potential clinic applications of magnesium supplementation for sepsis prevention and treatment. Twit Text FOAVip Magnesium protects against sepsis by blocking gasdermin D N-terminal-induced pyroptosis ????Cell Death Differ http://www.kidney.de/pget.php?&tw=1&pmid=31209359 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=31209359 #FOAvip English Wikipedia <ref>{{Cite pmid|31209359}}</ref> Magnesium protects against sepsis by blocking gasdermin D N-terminal-induced pyroptosis #MMPMID31209359 Wang D; Zheng J; Hu Q; Zhao C; Chen Q; Shi P; Chen Q; Zou Y; Zou D; Liu Q; Pei J; Wu X; Gao X; Ren J; Lin Z Cell Death Differ 2020[Feb]; 27 (2): 466-481 PMID31209359show ga Hypomagnesemia is a significant risk factor for critically ill patients to develop sepsis, a life-threatening disease with a mortality rate over 25%. Our clinic data analysis showed that hypomagnesemia is associated with a decreased monocyte count in septic patients. At the cellular level, we found that Mg(2+) inhibits pyroptosis. Specifically, Mg(2+) limits the oligomerization and membrane localization of gasdermin D N-terminal (GSDMD-NT) upon the activation of either the canonical or noncanonical pyroptotic pathway. Mechanistically, we demonstrated that Ca(2+) influx is a prerequisite for the function of GSDMD-NT. Mg(2+) blocks Ca(2+) influx by inhibiting the ATP-gated Ca(2+) channel P2X7, thereby impeding the function of GSDMD-NT and inhibiting lipopolysaccharide (LPS)-induced noncanonical pyroptosis. Furthermore, Mg(2+) administration protects mice from LPS-induced lethal septic shock. Together, our data reveal the underlying mechanism of how Mg(2+) inhibits pyroptosis and suggest potential clinic applications of magnesium supplementation for sepsis prevention and treatment. |Animals[MESH] |Cells, Cultured[MESH] |HEK293 Cells[MESH] |Humans[MESH] |Intracellular Signaling Peptides and Proteins/*antagonists & inhibitors/metabolism[MESH] |Lipopolysaccharides/administration & dosage/antagonists & inhibitors/pharmacology[MESH] |Magnesium/blood/*pharmacology[MESH] |Male[MESH] |Mice[MESH] |Mice, Inbred C57BL[MESH] |Phosphate-Binding Proteins/*antagonists & inhibitors/metabolism[MESH] |Pyroptosis/*drug effects[MESH]Magnesium protects against sepsis by blocking gasdermin D N-terminal-i(epmc).pdf DeepDyve Pubget Overpricing