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10.12932/AP-091018-0412 http://scihub22266oqcxt.onion/10.12932/AP-091018-0412 31175714!ä!31175714 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Asian+Pac+J+Allergy+Immunol 2021 ; 39 (1): 15-24 Nephropedia Template TP {{tp|p=31175714|t=2021. Magnesium augments immunosuppressive effects of a corticosteroid in obese mice with airway inflammation |pdf=|usr=}}{{31175714}} gab.com Text Magnesium augments immunosuppressive effects of a corticosteroid in obese mice with airway inflammation JO: Asian Pac J Allergy Immunol http://www.kidney.de/pget.php?&tw=1&pmid=31175714 #FOAvip BACKGROUND: Magnesium deficiency common in obesity is known to promote chronic low-grade inflammation and aggravate asthma symptoms; however, the effects of magnesium supplementation in obese asthmatic patients have not been investigated. OBJECTIVE: To examine the effects of magnesium co-administration with dexamethasone on airway inflammation in obese mice. METHODS: Female C57BL/6 mice were fed a high-fat diet, sensitized with ovalbumin (OVA) to induce allergic reactions, challenged with aerosolized OVA, and administered dexamethasone (3 mg/kg) with or without magnesium. Bronchial inflammation was analyzed based on the presence of inflammatory cells and cytokines in bronchoalveolar lavage fluid, total and OVA-specific IgE in serum, goblet cells ratios, bronchial wall thickness, and expression of alpha-smooth muscle actin. RESULTS: In obese mice, co-administration of magnesium and dexamethasone decreased IL-13 in bronchoalveolar lavage fluid and total and OVA-specific IgE in serum, and reduced alpha-smooth muscle actin-positive areas in the bronchi compared with mice treated with dexamethasone alone. However, no differences were observed in dexamethasone-treated normal-weight mice depending on magnesium supplementation. CONCLUSION: These results suggest that magnesium increases immunosuppressive effects of dexamethasone in airway inflammation aggravated by obesity, suggesting that magnesium supplementation may have a potential in alleviating asthma symptoms in obese patients with reduced responses to corticosteroids. Twit Text FOAVip Magnesium augments immunosuppressive effects of a corticosteroid in obese mice with airway inflammation ????Asian Pac J Allergy Immunol http://www.kidney.de/pget.php?&tw=1&pmid=31175714 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=31175714 #FOAvip English Wikipedia <ref>{{Cite pmid|31175714}}</ref> Magnesium augments immunosuppressive effects of a corticosteroid in obese mice with airway inflammation #MMPMID31175714 Moon J; Cho ES; Lee MY; Son HY; Lee K Asian Pac J Allergy Immunol 2021[Mar]; 39 (1): 15-24 PMID31175714show ga BACKGROUND: Magnesium deficiency common in obesity is known to promote chronic low-grade inflammation and aggravate asthma symptoms; however, the effects of magnesium supplementation in obese asthmatic patients have not been investigated. OBJECTIVE: To examine the effects of magnesium co-administration with dexamethasone on airway inflammation in obese mice. METHODS: Female C57BL/6 mice were fed a high-fat diet, sensitized with ovalbumin (OVA) to induce allergic reactions, challenged with aerosolized OVA, and administered dexamethasone (3 mg/kg) with or without magnesium. Bronchial inflammation was analyzed based on the presence of inflammatory cells and cytokines in bronchoalveolar lavage fluid, total and OVA-specific IgE in serum, goblet cells ratios, bronchial wall thickness, and expression of alpha-smooth muscle actin. RESULTS: In obese mice, co-administration of magnesium and dexamethasone decreased IL-13 in bronchoalveolar lavage fluid and total and OVA-specific IgE in serum, and reduced alpha-smooth muscle actin-positive areas in the bronchi compared with mice treated with dexamethasone alone. However, no differences were observed in dexamethasone-treated normal-weight mice depending on magnesium supplementation. CONCLUSION: These results suggest that magnesium increases immunosuppressive effects of dexamethasone in airway inflammation aggravated by obesity, suggesting that magnesium supplementation may have a potential in alleviating asthma symptoms in obese patients with reduced responses to corticosteroids. |Adrenal Cortex Hormones/*administration & dosage[MESH] |Animals[MESH] |Anti-Inflammatory Agents/*administration & dosage[MESH] |Asthma/blood/*drug therapy/immunology/pathology[MESH] |Bronchi/drug effects/pathology[MESH] |Bronchoalveolar Lavage Fluid/cytology/immunology[MESH] |Cell Count[MESH] |Cytokines/immunology[MESH] |Dexamethasone/*administration & dosage[MESH] |Diet, High-Fat[MESH] |Female[MESH] |Immunoglobulin E/blood[MESH] |Immunosuppressive Agents/*administration & dosage[MESH] |Inflammation/blood/drug therapy/immunology/pathology[MESH] |Magnesium/*administration & dosage[MESH] |Mice[MESH] |Mice, Inbred C57BL[MESH] |Obesity/blood/*drug therapy/immunology/pathology[MESH]Magnesium augments immunosuppressive effects of a corticosteroid in ob(epmc).pdf DeepDyve Pubget Overpricing