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10.18632/aging.101978 http://scihub22266oqcxt.onion/10.18632/aging.101978 31123221/?report=reader!6555457!31123221     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Aging+(Albany+NY) 2019 ; 11 (10): 3262-3279 Nephropedia Template TP {{tp|p=31123221|t=2019. Abnormal gut microbiota composition contributes to cognitive dysfunction in streptozotocin-induced diabetic mice |pdf=|usr=}}{{31123221}} gab.com Text Abnormal gut microbiota composition contributes to cognitive dysfunction in streptozotocin-induced diabetic mice JO: Aging (Albany NY) http://www.kidney.de/pget.php?&tw=1&pmid=31123221 #FOAvip Both diabetes and Alzheimer's disease are age-related disorders, and numerous studies have demonstrated that patients with diabetes are at an increased risk of cognitive dysfunction (CD) and Alzheimer's disease, suggesting shared or interacting pathomechanisms. The present study investigated the role of abnormal gut microbiota in diabetes-induced CD and the potential underlying mechanisms. An intraperitoneal injection of streptozotocin administered for 5 consecutive days was used for establishing a diabetic animal model. Hierarchical cluster analysis of Morris water maze (MWM) performance indices (escape latency and target quadrant crossing) was adopted to classify the diabetic model mice into CD and Non-CD phenotypes. Both beta-diversity and relative abundance of several gut bacteria significantly differed between the CD and Non-CD groups. Further, fecal bacteria transplantation from Non-CD mice, but not from CD mice, into the gut of pseudo-germ-free mice significantly improved host MWM performance, an effect associated with alterations in beta-diversity and relative abundance of host gut bacteria. Collectively, these findings suggest that abnormal gut microbiota composition contributes to the onset of diabetes-induced CD and that improving gut microbiota composition is a potential therapeutic strategy for diabetes and related comorbidities. Twit Text FOAVip Abnormal gut microbiota composition contributes to cognitive dysfunction in streptozotocin-induced diabetic mice ????Aging (Albany NY) http://www.kidney.de/pget.php?&tw=1&pmid=31123221 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=31123221 #FOAvip English Wikipedia <ref>{{Cite pmid|31123221}}</ref> Abnormal gut microbiota composition contributes to cognitive dysfunction in streptozotocin-induced diabetic mice #MMPMID31123221 Yu F; Han W; Zhan G; Li S; Xiang S; Zhu B; Jiang X; Yang L; Luo A; Hua F; Yang C Aging (Albany NY) 2019[May]; 11 (10): 3262-3279 PMID31123221show ga Both diabetes and Alzheimer's disease are age-related disorders, and numerous studies have demonstrated that patients with diabetes are at an increased risk of cognitive dysfunction (CD) and Alzheimer's disease, suggesting shared or interacting pathomechanisms. The present study investigated the role of abnormal gut microbiota in diabetes-induced CD and the potential underlying mechanisms. An intraperitoneal injection of streptozotocin administered for 5 consecutive days was used for establishing a diabetic animal model. Hierarchical cluster analysis of Morris water maze (MWM) performance indices (escape latency and target quadrant crossing) was adopted to classify the diabetic model mice into CD and Non-CD phenotypes. Both beta-diversity and relative abundance of several gut bacteria significantly differed between the CD and Non-CD groups. Further, fecal bacteria transplantation from Non-CD mice, but not from CD mice, into the gut of pseudo-germ-free mice significantly improved host MWM performance, an effect associated with alterations in beta-diversity and relative abundance of host gut bacteria. Collectively, these findings suggest that abnormal gut microbiota composition contributes to the onset of diabetes-induced CD and that improving gut microbiota composition is a potential therapeutic strategy for diabetes and related comorbidities. |*Gastrointestinal Microbiome[MESH] |*Spatial Memory[MESH] |Animals[MESH] |Cognitive Dysfunction/*etiology[MESH] |Diabetes Mellitus, Experimental/*complications/microbiology[MESH] |Fecal Microbiota Transplantation[MESH] |Mice, Inbred C57BL[MESH]Abnormal gut microbiota composition contributes to cognitive dysfuncti(epmc).pdf DeepDyve Pubget Overpricing