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10.1002/ardp.201800330 http://scihub22266oqcxt.onion/10.1002/ardp.201800330 31073993!7161747!31073993     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=31073993&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Arch+Pharm+(Weinheim) 2019 ; 352 (6): e1800330 Nephropedia Template TP {{tp|p=31073993|t=2019. Synthesis and anti-coronavirus activity of a series of 1-thia-4-azaspiro 4 5 decan-3-one derivatives |pdf=|usr=}}{{31073993}} gab.com Text Synthesis and anti-coronavirus activity of a series of 1-thia-4-azaspiro 4 5 decan-3-one derivatives JO: Arch Pharm (Weinheim) http://www.kidney.de/pget.php?&tw=1&pmid=31073993 #FOAvip A series of 1-thia-4-azaspiro[4.5]decan-3-ones bearing an amide group at C-4 and various substitutions at C-2 and C-8 were synthesized and evaluated against human coronavirus and influenza virus. Compounds 7m, 7n, 8k, 8l, 8m, 8n, and 8p were found to inhibit human coronavirus 229E replication. The most active compound was N-(2-methyl-8-tert-butyl-3-oxo-1-thia-4-azaspiro[4.5]decan-4-yl)-3-phenylpropanamide (8n), with an EC(50) value of 5.5 microM, comparable to the known coronavirus inhibitor, (Z)-N-[3-[4-(4-bromophenyl)-4-hydroxypiperidin-1-yl]-3-oxo-1-phenylprop-1-en-2-yl]benzamide (K22). Compound 8n and structural analogs were devoid of anti-influenza virus activity, although their scaffold is shared with a previously discovered class of H3 hemagglutinin-specific influenza virus fusion inhibitors. These findings point to the 1-thia-4-azaspiro[4.5]decan-3-one scaffold as a versatile chemical structure with high relevance for antiviral drug development. Twit Text FOAVip Synthesis and anti-coronavirus activity of a series of 1-thia-4-azaspiro 4 5 decan-3-one derivatives ????Arch Pharm (Weinheim) http://www.kidney.de/pget.php?&tw=1&pmid=31073993 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=31073993 #FOAvip English Wikipedia <ref>{{Cite pmid|31073993}}</ref> Synthesis and anti-coronavirus activity of a series of 1-thia-4-azaspiro 4 5 decan-3-one derivatives #MMPMID31073993 Apaydin CB; Cesur N; Stevaert A; Naesens L; Cesur Z Arch Pharm (Weinheim) 2019[Jun]; 352 (6): e1800330 PMID31073993show ga A series of 1-thia-4-azaspiro[4.5]decan-3-ones bearing an amide group at C-4 and various substitutions at C-2 and C-8 were synthesized and evaluated against human coronavirus and influenza virus. Compounds 7m, 7n, 8k, 8l, 8m, 8n, and 8p were found to inhibit human coronavirus 229E replication. The most active compound was N-(2-methyl-8-tert-butyl-3-oxo-1-thia-4-azaspiro[4.5]decan-4-yl)-3-phenylpropanamide (8n), with an EC(50) value of 5.5 microM, comparable to the known coronavirus inhibitor, (Z)-N-[3-[4-(4-bromophenyl)-4-hydroxypiperidin-1-yl]-3-oxo-1-phenylprop-1-en-2-yl]benzamide (K22). Compound 8n and structural analogs were devoid of anti-influenza virus activity, although their scaffold is shared with a previously discovered class of H3 hemagglutinin-specific influenza virus fusion inhibitors. These findings point to the 1-thia-4-azaspiro[4.5]decan-3-one scaffold as a versatile chemical structure with high relevance for antiviral drug development. |*Drug Design[MESH] |Animals[MESH] |Antiviral Agents/*chemical synthesis/chemistry/pharmacology[MESH] |Aza Compounds/*chemical synthesis/chemistry/pharmacology[MESH] |Coronavirus/*drug effects[MESH] |Cytopathogenic Effect, Viral/drug effects[MESH] |Dogs[MESH] |Fibroblasts/drug effects/virology[MESH] |Humans[MESH] |Madin Darby Canine Kidney Cells[MESH] |Molecular Structure[MESH] |Spiro Compounds/*chemical synthesis/chemistry/pharmacology[MESH] |Structure-Activity Relationship[MESH]Synthesis and anti-coronavirus activity of a series of 1-thia-4-azasp(epmc).pdf DeepDyve Pubget Overpricing