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10.1055/s-0039-1685503

http://scihub22266oqcxt.onion/10.1055/s-0039-1685503
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suck abstract from ncbi


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pmid31044099      AJP+Rep 2019 ; 9 (2): e167-e171
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  • Efficacy of Non-Beta-lactam Antibiotics for Prevention of Cesarean Delivery Surgical Site Infections #MMPMID31044099
  • Harris BS; Hopkins MK; Villers MS; Weber JM; Pieper C; Grotegut CA; Swamy GK; Hughes BL; Heine RP
  • AJP Rep 2019[Apr]; 9 (2): e167-e171 PMID31044099show ga
  • Objective To examine the association between perioperative Beta ( beta ))-lactam versus non- beta -lactam antibiotics and cesarean delivery surgical site infection (SSI). Study Design Retrospective cohort of women undergoing cesarean delivery from January 1 to December 31, 2014. All women undergoing cesarean after 34 weeks with a postpartum visit were included. Prevalence of SSI was compared between women receiving beta -lactam versus non- beta -lactam antibiotics. Bivariate analyses were performed using Pearson's Chi-square, Fisher's exact, or Wilcoxon's rank-sum tests. Logistic regression models were fit controlling for possible confounders. Results Of the 929 women included, 826 (89%) received beta -lactam prophylaxis and 103 (11%) received a non- beta -lactam. Among the 893 women who reported a non-type I (low risk) allergy, 819 (92%) received beta -lactam prophylaxis. SSI occurred in 7% of women who received beta -lactam antibiotics versus 15% of women who received a non- beta -lactam ( p = 0.004). beta -Lactam prophylaxis was associated with lower odds of SSI compared with non- beta -lactam antibiotics (odds ratio [OR] = 0.43; 95% confidence interval [CI] = 0.22-0.83; p = 0.01) after controlling for chorioamnionitis in labor, postlabor cesarean, endometritis, tobacco use, and body mass index (BMI). Conclusion beta -Lactam perioperative prophylaxis is associated with lower odds of a cesarean delivery surgical site infection compared with non- beta -lactam antibiotics.
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