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10.18632/aging.101925 http://scihub22266oqcxt.onion/10.18632/aging.101925 31029057/?report=reader!6520009!31029057     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Aging+(Albany+NY) 2019 ; 11 (8): 2420-2429 Nephropedia Template TP {{tp|p=31029057|t=2019. Diagnostic performance of new and classic CSF biomarkers in age-related dementias |pdf=|usr=}}{{31029057}} gab.com Text Diagnostic performance of new and classic CSF biomarkers in age-related dementias JO: Aging (Albany NY) http://www.kidney.de/pget.php?&tw=1&pmid=31029057 #FOAvip The identification of diagnostic-prognostic biomarkers of dementia has become a global priority due to the prevalence of neurodegenerative diseases in aging populations. The objective of this study was to assess the diagnostic performance of cerebrospinal fluid (CSF) biomarkers across patients affected by either Alzheimer's disease (AD), tauopathies other than AD (TP), or vascular dementia (VD), and cognitively normal subjects (CNS). One hundred fifty-three patients were recruited and tested for classical AD CSF biomarkers- Amyloid-ss42 and tau proteins - and novel candidate biomarkers - neurofilament (NF-) light and microRNA (miR) -21, -125b, -146a, and -222.All dementia patients had significantly higher concentrations of NF-light compared to CNS, with the TP group displaying the highest NF-light values. A significant inverse correlation was also observed between NF-light and cognitive impairment. Of the four miRNAs analyzed, miR-222 levels were significantly increased in VD patients compared to both CNS and AD. In addition, while NF-light showed a better diagnostic performance than miR-222 and classical AD biomarkers in differentiating TP and VD from CNS, classical AD biomarkers revealed higher performance in discriminating AD from non-AD disorders.Overall, our results suggest that CSF NF-light and miR-222 are promising biomarkers that may help to diagnose non-AD disorders. Twit Text FOAVip Diagnostic performance of new and classic CSF biomarkers in age-related dementias ????Aging (Albany NY) http://www.kidney.de/pget.php?&tw=1&pmid=31029057 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=31029057 #FOAvip English Wikipedia <ref>{{Cite pmid|31029057}}</ref> Diagnostic performance of new and classic CSF biomarkers in age-related dementias #MMPMID31029057 Marchegiani F; Matacchione G; Ramini D; Marcheselli F; Recchioni R; Casoli T; Mercuri E; Lazzarini M; Giorgetti B; Cameriere V; Paolini S; Paciaroni L; Rossi T; Galeazzi R; Lisa R; Bonfigli AR; Procopio AD; De Luca M; Pelliccioni G; Olivieri F Aging (Albany NY) 2019[Apr]; 11 (8): 2420-2429 PMID31029057show ga The identification of diagnostic-prognostic biomarkers of dementia has become a global priority due to the prevalence of neurodegenerative diseases in aging populations. The objective of this study was to assess the diagnostic performance of cerebrospinal fluid (CSF) biomarkers across patients affected by either Alzheimer's disease (AD), tauopathies other than AD (TP), or vascular dementia (VD), and cognitively normal subjects (CNS). One hundred fifty-three patients were recruited and tested for classical AD CSF biomarkers- Amyloid-ss42 and tau proteins - and novel candidate biomarkers - neurofilament (NF-) light and microRNA (miR) -21, -125b, -146a, and -222.All dementia patients had significantly higher concentrations of NF-light compared to CNS, with the TP group displaying the highest NF-light values. A significant inverse correlation was also observed between NF-light and cognitive impairment. Of the four miRNAs analyzed, miR-222 levels were significantly increased in VD patients compared to both CNS and AD. In addition, while NF-light showed a better diagnostic performance than miR-222 and classical AD biomarkers in differentiating TP and VD from CNS, classical AD biomarkers revealed higher performance in discriminating AD from non-AD disorders.Overall, our results suggest that CSF NF-light and miR-222 are promising biomarkers that may help to diagnose non-AD disorders. |Aged[MESH] |Aged, 80 and over[MESH] |Alzheimer Disease/cerebrospinal fluid/*diagnosis[MESH] |Amyloid beta-Peptides/*cerebrospinal fluid[MESH] |Biomarkers/cerebrospinal fluid[MESH] |Dementia, Vascular/cerebrospinal fluid/*diagnosis[MESH] |Female[MESH] |Humans[MESH] |Male[MESH] |Middle Aged[MESH] |Neurofilament Proteins/*cerebrospinal fluid[MESH] |Peptide Fragments/*cerebrospinal fluid[MESH] |Tauopathies/cerebrospinal fluid/*diagnosis[MESH]Diagnostic performance of new and classic CSF biomarkers in age-relate(epmc).pdf DeepDyve Pubget Overpricing