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10.3892/etm.2019.7457 http://scihub22266oqcxt.onion/10.3892/etm.2019.7457 31007736!6468397!31007736     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=31007736&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Exp+Ther+Med 2019 ; 17 (5): 3935-3942 Nephropedia Template TP {{tp|p=31007736|t=2019. let-7a suppresses liver fibrosis via TGFbeta/SMAD signaling transduction pathway |pdf=|usr=}}{{31007736}} gab.com Text let-7a suppresses liver fibrosis via TGFbeta/SMAD signaling transduction pathway JO: Exp Ther Med http://www.kidney.de/pget.php?&tw=1&pmid=31007736 #FOAvip Liver fibrosis is the most common pathological outcome and the most severe complication of chronic liver diseases. Accumulating evidence suggests that miRNAs are involved in cell proliferation, differentiation, apoptosis, as well as the occurrence and development of various diseases. In this study, we found that the expression of let-7a was markedly decreased in the liver tissue samples and blood samples from patients with liver fibrosis compared with healthy volunteers. Furthermore, let-7a was downregulated in the liver tissues and blood samples in mouse models of liver fibrosis. Further analysis indicated that let-7a suppresses the activation level of hepatic stellate cells (HSCs). In addition, overexpression of let-7a reduced cell viability and promoted apoptosis of HSCs. Western blot analysis showed that let-7a might inhibit HSCs through TGFbeta/SMAD signaling pathway. The present study provides a potential accurate target and vital evidence to better understand the underlying pathogenesis for early diagnosis and treatment of liver fibrosis. Twit Text FOAVip let-7a suppresses liver fibrosis via TGFbeta/SMAD signaling transduction pathway ????Exp Ther Med http://www.kidney.de/pget.php?&tw=1&pmid=31007736 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=31007736 #FOAvip English Wikipedia <ref>{{Cite pmid|31007736}}</ref> let-7a suppresses liver fibrosis via TGFbeta/SMAD signaling transduction pathway #MMPMID31007736 Zhang Y; Guo J; Li Y; Jiao K; Zhang Y Exp Ther Med 2019[May]; 17 (5): 3935-3942 PMID31007736show ga Liver fibrosis is the most common pathological outcome and the most severe complication of chronic liver diseases. Accumulating evidence suggests that miRNAs are involved in cell proliferation, differentiation, apoptosis, as well as the occurrence and development of various diseases. In this study, we found that the expression of let-7a was markedly decreased in the liver tissue samples and blood samples from patients with liver fibrosis compared with healthy volunteers. Furthermore, let-7a was downregulated in the liver tissues and blood samples in mouse models of liver fibrosis. Further analysis indicated that let-7a suppresses the activation level of hepatic stellate cells (HSCs). In addition, overexpression of let-7a reduced cell viability and promoted apoptosis of HSCs. Western blot analysis showed that let-7a might inhibit HSCs through TGFbeta/SMAD signaling pathway. The present study provides a potential accurate target and vital evidence to better understand the underlying pathogenesis for early diagnosis and treatment of liver fibrosis. ?let-7a suppresses liver fibrosis via TGFbeta/SMAD signaling transducti(epmc).pdf DeepDyve Pubget Overpricing