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10.1016/j.bbrc.2019.03.178 http://scihub22266oqcxt.onion/10.1016/j.bbrc.2019.03.178 30952425!?!30952425 Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=30952425&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Biochem+Biophys+Res+Commun 2019 ; 513 (1): 159-165 Nephropedia Template TP {{tp|p=30952425|t=2019. The simultaneous downregulation of TRPM7 and MagT1 in human mesenchymal stem cells in vitro: Effects on growth and osteogenic differentiation |pdf=|usr=}}{{30952425}} gab.com Text The simultaneous downregulation of TRPM7 and MagT1 in human mesenchymal stem cells in vitro: Effects on growth and osteogenic differentiation JO: Biochem Biophys Res Commun http://www.kidney.de/pget.php?&tw=1&pmid=30952425 #FOAvip The magnesium transporters TRPM7 and MagT1 are overexpressed in osteoblastogenesis. We have shown that silencing either TRPM7 or MagT1 accelerates the osteogenic differentiation of human bone mesenchymal stem cells. Here we demonstrate that the simultaneous downregulation of TRPM7 and MagT1 inhibits cell growth and activates autophagy, which is required in the early phases of osteoblastogenesis. In TRPM7/MagT1 downregulating cells the expression of two transcription factors required for activating osteogenesis, i.e. RUNX2 and OSTERIX, is induced more than in the controls both in the presence and in the absence of osteogenic stimuli, while COL1A1 is upregulated in co-silencing cells as much as in the controls. This explains why we found no differences in calcium deposition. We conclude that one of the two transporters should be expressed to accelerate osteogenic differentiation. Twit Text FOAVip The simultaneous downregulation of TRPM7 and MagT1 in human mesenchymal stem cells in vitro: Effects on growth and osteogenic differentiation ????Biochem Biophys Res Commun http://www.kidney.de/pget.php?&tw=1&pmid=30952425 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=30952425 #FOAvip English Wikipedia <ref>{{Cite pmid|30952425}}</ref> The simultaneous downregulation of TRPM7 and MagT1 in human mesenchymal stem cells in vitro: Effects on growth and osteogenic differentiation #MMPMID30952425 Castiglioni S; Romeo V; Locatelli L; Zocchi M; Zecchini S; Maier JAM Biochem Biophys Res Commun 2019[May]; 513 (1): 159-165 PMID30952425show ga The magnesium transporters TRPM7 and MagT1 are overexpressed in osteoblastogenesis. We have shown that silencing either TRPM7 or MagT1 accelerates the osteogenic differentiation of human bone mesenchymal stem cells. Here we demonstrate that the simultaneous downregulation of TRPM7 and MagT1 inhibits cell growth and activates autophagy, which is required in the early phases of osteoblastogenesis. In TRPM7/MagT1 downregulating cells the expression of two transcription factors required for activating osteogenesis, i.e. RUNX2 and OSTERIX, is induced more than in the controls both in the presence and in the absence of osteogenic stimuli, while COL1A1 is upregulated in co-silencing cells as much as in the controls. This explains why we found no differences in calcium deposition. We conclude that one of the two transporters should be expressed to accelerate osteogenic differentiation. |Adult[MESH] |Autophagy[MESH] |Cation Transport Proteins/*genetics/metabolism[MESH] |Cell Differentiation[MESH] |Cell Proliferation[MESH] |Cells, Cultured[MESH] |Down-Regulation[MESH] |Humans[MESH] |Mesenchymal Stem Cells/*cytology/metabolism[MESH] |Osteogenesis[MESH] |Protein Serine-Threonine Kinases/*genetics/metabolism[MESH] |RNA Interference[MESH]The simultaneous downregulation of TRPM7 and MagT1 in human mesenchyma(epmc).pdf DeepDyve Pubget Overpricing