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10.15252/embj.2018100941 http://scihub22266oqcxt.onion/10.15252/embj.2018100941 30872283!6463209!30872283     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       EMBO+J 2019 ; 38 (8): ä Nephropedia Template TP {{tp|p=30872283|t=2019. Slicing and dicing viruses: antiviral RNA interference in mammals |pdf=|usr=}}{{30872283}} gab.com Text Slicing and dicing viruses: antiviral RNA interference in mammals JO: EMBO J http://www.kidney.de/pget.php?&tw=1&pmid=30872283 #FOAvip To protect against the harmful consequences of viral infections, organisms are equipped with sophisticated antiviral mechanisms, including cell-intrinsic means to restrict viral replication and propagation. Plant and invertebrate cells utilise mostly RNA interference (RNAi), an RNA-based mechanism, for cell-intrinsic immunity to viruses while vertebrates rely on the protein-based interferon (IFN)-driven innate immune system for the same purpose. The RNAi machinery is conserved in vertebrate cells, yet whether antiviral RNAi is still active in mammals and functionally relevant to mammalian antiviral defence is intensely debated. Here, we discuss cellular and viral factors that impact on antiviral RNAi and the contexts in which this system might be at play in mammalian resistance to viral infection. Twit Text FOAVip Slicing and dicing viruses: antiviral RNA interference in mammals ????EMBO J http://www.kidney.de/pget.php?&tw=1&pmid=30872283 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=30872283 #FOAvip English Wikipedia <ref>{{Cite pmid|30872283}}</ref> Slicing and dicing viruses: antiviral RNA interference in mammals #MMPMID30872283 Maillard PV; van der Veen AG; Poirier EZ; Reis e Sousa C EMBO J 2019[Apr]; 38 (8): ä PMID30872283show ga To protect against the harmful consequences of viral infections, organisms are equipped with sophisticated antiviral mechanisms, including cell-intrinsic means to restrict viral replication and propagation. Plant and invertebrate cells utilise mostly RNA interference (RNAi), an RNA-based mechanism, for cell-intrinsic immunity to viruses while vertebrates rely on the protein-based interferon (IFN)-driven innate immune system for the same purpose. The RNAi machinery is conserved in vertebrate cells, yet whether antiviral RNAi is still active in mammals and functionally relevant to mammalian antiviral defence is intensely debated. Here, we discuss cellular and viral factors that impact on antiviral RNAi and the contexts in which this system might be at play in mammalian resistance to viral infection. |*RNA Interference[MESH] |Animals[MESH] |Antiviral Agents/administration & dosage[MESH] |Host-Pathogen Interactions/genetics/*immunology[MESH] |Mammals/genetics/*immunology/virology[MESH] |RNA, Viral/*genetics[MESH] |Virus Diseases/genetics/*immunology/virology[MESH] |Virus Replication[MESH]Slicing and dicing viruses: antiviral RNA interference in mammals (epmc).pdf DeepDyve Pubget Overpricing