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10.3390/ijms20051135 http://scihub22266oqcxt.onion/10.3390/ijms20051135 30845649!6429129!30845649     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Int+J+Mol+Sci 2019 ; 20 (5): ä Nephropedia Template TP {{tp|p=30845649|t=2019. Current Structural Knowledge on the CNNM Family of Magnesium Transport Mediators |pdf=|usr=}}{{30845649}} gab.com Text Current Structural Knowledge on the CNNM Family of Magnesium Transport Mediators JO: Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=30845649 #FOAvip The cyclin and cystathionine beta-synthase (CBS) domain magnesium transport mediators, CNNMs, are key players in maintaining the homeostasis of magnesium in different organs. The human family includes four members, whose impaired activity causes diseases such as Jalili Syndrome or Familial Hypomagnesemia, but is also linked to neuropathologic disorders, altered blood pressure, and infertility. Recent findings demonstrated that CNNMs are associated with the highly oncogenic phosphatases of the regenerating liver to promote tumor growth and metastasis, which has attracted renewed focus on their potential exploitation as targets for cancer treatment. However, the exact function of CNNMs remains unclear and is subject to debate, proposed as either direct transporters, sensors, or homeostatic factors. This review gathers the current structural knowledge on the CNNM family, highlighting similarities and differences with the closely related structural partners such as the bacterial Mg(2+)/Co(2+) efflux protein CorC and the Mg(2+) channel MgtE. Twit Text FOAVip Current Structural Knowledge on the CNNM Family of Magnesium Transport Mediators ????Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=30845649 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=30845649 #FOAvip English Wikipedia <ref>{{Cite pmid|30845649}}</ref> Current Structural Knowledge on the CNNM Family of Magnesium Transport Mediators #MMPMID30845649 Gimenez-Mascarell P; Gonzalez-Recio I; Fernandez-Rodriguez C; Oyenarte I; Muller D; Martinez-Chantar ML; Martinez-Cruz LA Int J Mol Sci 2019[Mar]; 20 (5): ä PMID30845649show ga The cyclin and cystathionine beta-synthase (CBS) domain magnesium transport mediators, CNNMs, are key players in maintaining the homeostasis of magnesium in different organs. The human family includes four members, whose impaired activity causes diseases such as Jalili Syndrome or Familial Hypomagnesemia, but is also linked to neuropathologic disorders, altered blood pressure, and infertility. Recent findings demonstrated that CNNMs are associated with the highly oncogenic phosphatases of the regenerating liver to promote tumor growth and metastasis, which has attracted renewed focus on their potential exploitation as targets for cancer treatment. However, the exact function of CNNMs remains unclear and is subject to debate, proposed as either direct transporters, sensors, or homeostatic factors. This review gathers the current structural knowledge on the CNNM family, highlighting similarities and differences with the closely related structural partners such as the bacterial Mg(2+)/Co(2+) efflux protein CorC and the Mg(2+) channel MgtE. |Cation Transport Proteins/*chemistry/genetics/*metabolism[MESH] |Crystallography, X-Ray[MESH] |Humans[MESH] |Magnesium/*metabolism[MESH] |Models, Molecular[MESH] |Mutation[MESH] |Neoplasms/genetics/metabolism[MESH] |Phosphoric Monoester Hydrolases/metabolism[MESH]Current Structural Knowledge on the CNNM Family of Magnesium Transport(epmc).pdf DeepDyve Pubget Overpricing