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10.1080/14767058.2019.1583735 http://scihub22266oqcxt.onion/10.1080/14767058.2019.1583735 30835601!ä!30835601 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Matern+Fetal+Neonatal+Med 2020 ; 33 (22): 3732-3739 Nephropedia Template TP {{tp|p=30835601|t=2020. Fetal neuroprotective mechanism of maternal magnesium sulfate for late gestation inflammation: in a rodent model |pdf=|usr=}}{{30835601}} gab.com Text Fetal neuroprotective mechanism of maternal magnesium sulfate for late gestation inflammation: in a rodent model JO: J Matern Fetal Neonatal Med http://www.kidney.de/pget.php?&tw=1&pmid=30835601 #FOAvip Background: Maternal administration of magnesium sulfate (Mg) is used in humans to protect the fetal brain during preterm delivery. We sought to determine the neuroprotective mechanism of Mg in a rat model of late gestation maternal inflammation.Methods: Pregnant rats at 20 d of gestation (20 total, four groups, N = 5 in each group) received i.p. LPS or saline. Dams were randomized for s.c. saline or Mg supplementation 2 h prior and following the LPS/saline injections. Dams were sacrificed 4 h following the last treatment. Fetal brains were collected from the four treatment groups. Fetal brain caspase 3 active form, NF-kB p65, neuronal nitric oxide synthase (phospho-nNos), and proinflammatory cytokines levels were determined by western blot.Results: Maternal LPS at e20 significantly (p < .01) increased fetal brain caspase 3 active form (af) (0.27 +/- 0.02 versus 0.15 +/- 0.06u), NFkB (0.23 +/- 0.01 versus 0.13 +/- 0.01u), and phospho-nNOS (0.22 +/- 0.01 versus 0.12 +/- 0.01u) and fetal brain proinflammatory cytokines (IL-6 0.21 +/- 0.01 versus 0.11 +/- 0.01 u; TNFalpha 0.29 +/- 0.01 versus 0.15 +/- 0.01u), compared with control fetuses. Mg treatment significantly (p < .05) reduced fetal brain caspase 3 af (0.16 +/- 0.01u), NFkB p65 (0.11 +/- 0.01u), phospho-nNOS (0.1 +/- 0.01u), as well as brain proinflammatory cytokines (IL-6 0.07 +/- 0.01u; TNFalpha 0.15 +/- 0.01u) to levels similar to controls.Conclusion: Maternal inflammation-induced fetal brain injury at late gestation may be mediated by the activation of inflammatory response, oxidative stress, and apoptosis. Maternal Mg may attenuate the injury by inhibition of these putative pathways. Twit Text FOAVip Fetal neuroprotective mechanism of maternal magnesium sulfate for late gestation inflammation: in a rodent model ????J Matern Fetal Neonatal Med http://www.kidney.de/pget.php?&tw=1&pmid=30835601 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=30835601 #FOAvip English Wikipedia <ref>{{Cite pmid|30835601}}</ref> Fetal neuroprotective mechanism of maternal magnesium sulfate for late gestation inflammation: in a rodent model #MMPMID30835601 Khatib N; Ginsberg Y; Shalom-Paz E; Dabaja H; Gutzeit O; Zmora O; Millo Z; Ross MG; Weiner Z; Beloosesky R J Matern Fetal Neonatal Med 2020[Nov]; 33 (22): 3732-3739 PMID30835601show ga Background: Maternal administration of magnesium sulfate (Mg) is used in humans to protect the fetal brain during preterm delivery. We sought to determine the neuroprotective mechanism of Mg in a rat model of late gestation maternal inflammation.Methods: Pregnant rats at 20 d of gestation (20 total, four groups, N = 5 in each group) received i.p. LPS or saline. Dams were randomized for s.c. saline or Mg supplementation 2 h prior and following the LPS/saline injections. Dams were sacrificed 4 h following the last treatment. Fetal brains were collected from the four treatment groups. Fetal brain caspase 3 active form, NF-kB p65, neuronal nitric oxide synthase (phospho-nNos), and proinflammatory cytokines levels were determined by western blot.Results: Maternal LPS at e20 significantly (p < .01) increased fetal brain caspase 3 active form (af) (0.27 +/- 0.02 versus 0.15 +/- 0.06u), NFkB (0.23 +/- 0.01 versus 0.13 +/- 0.01u), and phospho-nNOS (0.22 +/- 0.01 versus 0.12 +/- 0.01u) and fetal brain proinflammatory cytokines (IL-6 0.21 +/- 0.01 versus 0.11 +/- 0.01 u; TNFalpha 0.29 +/- 0.01 versus 0.15 +/- 0.01u), compared with control fetuses. Mg treatment significantly (p < .05) reduced fetal brain caspase 3 af (0.16 +/- 0.01u), NFkB p65 (0.11 +/- 0.01u), phospho-nNOS (0.1 +/- 0.01u), as well as brain proinflammatory cytokines (IL-6 0.07 +/- 0.01u; TNFalpha 0.15 +/- 0.01u) to levels similar to controls.Conclusion: Maternal inflammation-induced fetal brain injury at late gestation may be mediated by the activation of inflammatory response, oxidative stress, and apoptosis. Maternal Mg may attenuate the injury by inhibition of these putative pathways. |*Magnesium Sulfate/pharmacology[MESH] |*Rodentia[MESH] |Animals[MESH] |Brain[MESH] |Female[MESH] |Fetus[MESH] |Inflammation/drug therapy[MESH] |Lipopolysaccharides[MESH] |Pregnancy[MESH] |Rats[MESH]Fetal neuroprotective mechanism of maternal magnesium sulfate for late(epmc).pdf DeepDyve Pubget Overpricing