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10.1016/j.jcf.2019.02.004 http://scihub22266oqcxt.onion/10.1016/j.jcf.2019.02.004 30826285!6711838!30826285     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Cyst+Fibros 2019 ; 18 (6): 844-850 Nephropedia Template TP {{tp|p=30826285|t=2019. Early respiratory viral infections in infants with cystic fibrosis |pdf=|usr=}}{{30826285}} gab.com Text Early respiratory viral infections in infants with cystic fibrosis JO: J Cyst Fibros http://www.kidney.de/pget.php?&tw=1&pmid=30826285 #FOAvip BACKGROUND: Viral infections contribute to morbidity in cystic fibrosis (CF), but the impact of respiratory viruses on the development of airway disease is poorly understood. METHODS: Infants with CF identified by newborn screening were enrolled prior to 4?months of age to participate in a prospective observational study at 4 centers. Clinical data were collected at clinic visits and weekly phone calls. Multiplex PCR assays were performed on nasopharyngeal swabs to detect respiratory viruses during routine visits and when symptomatic. Participants underwent bronchoscopy with bronchoalveolar lavage (BAL) and a subset underwent pulmonary function testing. We present findings through 8.5?months of life. RESULTS: Seventy infants were enrolled, mean age 3.1?+/-?0.8?months. Rhinovirus was the most prevalent virus (66%), followed by parainfluenza (19%), and coronavirus (16%). Participants had a median of 1.5 viral positive swabs (range 0-10). Past viral infection was associated with elevated neutrophil concentrations and bacterial isolates in BAL fluid, including recovery of classic CF bacterial pathogens. When antibiotics were prescribed for respiratory-related indications, viruses were identified in 52% of those instances. CONCLUSIONS: Early viral infections were associated with greater neutrophilic inflammation and bacterial pathogens. Early viral infections appear to contribute to initiation of lower airway inflammation in infants with CF. Antibiotics were commonly prescribed in the setting of a viral infection. Future investigations examining longitudinal relationships between viral infections, airway microbiome, and antibiotic use will allow us to elucidate the interplay between these factors in young children with CF. Twit Text FOAVip Early respiratory viral infections in infants with cystic fibrosis ????J Cyst Fibros http://www.kidney.de/pget.php?&tw=1&pmid=30826285 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=30826285 #FOAvip English Wikipedia <ref>{{Cite pmid|30826285}}</ref> Early respiratory viral infections in infants with cystic fibrosis #MMPMID30826285 Deschamp AR; Hatch JE; Slaven JE; Gebregziabher N; Storch G; Hall GL; Stick S; Ranganathan S; Ferkol TW; Davis SD J Cyst Fibros 2019[Nov]; 18 (6): 844-850 PMID30826285show ga BACKGROUND: Viral infections contribute to morbidity in cystic fibrosis (CF), but the impact of respiratory viruses on the development of airway disease is poorly understood. METHODS: Infants with CF identified by newborn screening were enrolled prior to 4?months of age to participate in a prospective observational study at 4 centers. Clinical data were collected at clinic visits and weekly phone calls. Multiplex PCR assays were performed on nasopharyngeal swabs to detect respiratory viruses during routine visits and when symptomatic. Participants underwent bronchoscopy with bronchoalveolar lavage (BAL) and a subset underwent pulmonary function testing. We present findings through 8.5?months of life. RESULTS: Seventy infants were enrolled, mean age 3.1?+/-?0.8?months. Rhinovirus was the most prevalent virus (66%), followed by parainfluenza (19%), and coronavirus (16%). Participants had a median of 1.5 viral positive swabs (range 0-10). Past viral infection was associated with elevated neutrophil concentrations and bacterial isolates in BAL fluid, including recovery of classic CF bacterial pathogens. When antibiotics were prescribed for respiratory-related indications, viruses were identified in 52% of those instances. CONCLUSIONS: Early viral infections were associated with greater neutrophilic inflammation and bacterial pathogens. Early viral infections appear to contribute to initiation of lower airway inflammation in infants with CF. Antibiotics were commonly prescribed in the setting of a viral infection. Future investigations examining longitudinal relationships between viral infections, airway microbiome, and antibiotic use will allow us to elucidate the interplay between these factors in young children with CF. |Age Factors[MESH] |Anti-Bacterial Agents/therapeutic use[MESH] |Cystic Fibrosis/*complications/therapy/*virology[MESH] |Female[MESH] |Follow-Up Studies[MESH] |Humans[MESH] |Infant[MESH] |Male[MESH] |Practice Patterns, Physicians'[MESH] |Prospective Studies[MESH] |Respiratory Tract Infections/diagnosis/*epidemiology/*virology[MESH]Early respiratory viral infections in infants with cystic fibrosis (epmc).pdf DeepDyve Pubget Overpricing