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10.12659/AJCR.913472

http://scihub22266oqcxt.onion/10.12659/AJCR.913472
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30820022/?report=reader!6410603!30820022
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suck abstract from ncbi


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pmid30820022      Am+J+Case+Rep 2019 ; 20 (ä): 268-273
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  • Multidrug-Resistant Bovine Salmonellosis Predisposing for Severe Human Clostridial Myonecrosis #MMPMID30820022
  • Hussain C; Ball MK; McGwire BS
  • Am J Case Rep 2019[Mar]; 20 (ä): 268-273 PMID30820022show ga
  • BACKGROUND The overuse of antibiotics in animals promotes the development of multidrug-resistance predisposing for severe polymicrobial human infections. CASE REPORT We describe a case of spontaneous clostridial myonecrosis due to ulcerative colonic infection with multidrug-resistant Salmonella enterica subsp. enterica, serotype 4,[5],12: i: -. Serotyping of the colonic Salmonella isolate in the index case and the bovine farm outbreak isolates from where the patient worked indicated they were both serotype I 4,[5],12: i: -, which is linked with a multitude of large reported disease outbreaks. Further analysis revealed that they are highly genetically related and antibiotic susceptibility testing indicated that they are phenotypically identical. CONCLUSIONS Enteritis due to human acquisition of multidrug-resistant Salmonella from cattle led to the invasion and dissemination of Clostridium septicum resulting in devastating myonecrotic disease. This highlights the ramifications of co-existence and evolution of pathogenic bacteria in animals and humans and lends support to reducing the use of antibiotics in animals.
  • |*Drug Resistance, Multiple, Bacterial[MESH]
  • |Clostridium Infections/complications/*microbiology/pathology[MESH]
  • |Clostridium septicum/*isolation & purification[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Muscle, Skeletal/*pathology[MESH]
  • |Necrosis[MESH]
  • |Salmonella Infections/complications/*microbiology/pathology[MESH]
  • |Salmonella enterica/*isolation & purification[MESH]


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