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10.1002/jmv.25441 http://scihub22266oqcxt.onion/10.1002/jmv.25441 30815882!7166372!30815882     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Med+Virol 2019 ; 91 (7): 1250-1262 Nephropedia Template TP {{tp|p=30815882|t=2019. Human adenovirus replication and persistence in hypertrophic adenoids and palatine tonsils in children |pdf=|usr=}}{{30815882}} gab.com Text Human adenovirus replication and persistence in hypertrophic adenoids and palatine tonsils in children JO: J Med Virol http://www.kidney.de/pget.php?&tw=1&pmid=30815882 #FOAvip The role of human adenovirus (HAdV) infection in different acute diseases, such as febrile exudative tonsillitis, conjunctivitis, and pharyngoconjunctival fever is well established. However, the relationships, if any, of HAdV persistence and reactivation in the development of the chronic adenotonsillar disease is not fully understood. The present paper reports a 3-year cross-sectional hospital-based study aimed at detecting and quantifying HAdV DNA and mRNA of the HAdV hexon gene in adenoid and palatine tonsil tissues and nasopharyngeal secretions (NPS) from patients with adenotonsillar hypertrophy or recurrent adenotonsillitis. HAdV C, B, and E were detectable in nearly 50% of the patients, with no association with the severity of airway obstruction, nor with the presence of recurrent tonsillitis, sleep apnea or otitis media with effusion (OME). Despite the higher rates of respiratory viral coinfections in patients with HAdV, the presence of other viruses, including DNA and RNA viruses, had no association with HAdV replication or shedding in secretions. Higher HAdV loads in adenoids showed a significant positive correlation with the presence of sleep apnea and the absence of OME. Although this study indicates that a significant proportion (~85%) of individuals with chronic adenotonsillar diseases have persistent nonproductive HAdV infection, including those by HAdV C, B, and E, epithelial and subepithelial cells in tonsils seem to be critical for HAdV C production and shedding in NPS in some patients, since viral antigen was detected in these regions by immunohistochemistry in four patients, all of which were also positive for HAdV mRNA detection. Twit Text FOAVip Human adenovirus replication and persistence in hypertrophic adenoids and palatine tonsils in children ????J Med Virol http://www.kidney.de/pget.php?&tw=1&pmid=30815882 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=30815882 #FOAvip English Wikipedia <ref>{{Cite pmid|30815882}}</ref> Human adenovirus replication and persistence in hypertrophic adenoids and palatine tonsils in children #MMPMID30815882 Proenca-Modena JL; de Souza Cardoso R; Criado MF; Milanez GP; de Souza WM; Parise PL; Bertol JW; de Jesus BLS; Prates MCM; Silva ML; Buzatto GP; Demarco RC; Valera FCP; Tamashiro E; Anselmo-Lima WT; Arruda E J Med Virol 2019[Jul]; 91 (7): 1250-1262 PMID30815882show ga The role of human adenovirus (HAdV) infection in different acute diseases, such as febrile exudative tonsillitis, conjunctivitis, and pharyngoconjunctival fever is well established. However, the relationships, if any, of HAdV persistence and reactivation in the development of the chronic adenotonsillar disease is not fully understood. The present paper reports a 3-year cross-sectional hospital-based study aimed at detecting and quantifying HAdV DNA and mRNA of the HAdV hexon gene in adenoid and palatine tonsil tissues and nasopharyngeal secretions (NPS) from patients with adenotonsillar hypertrophy or recurrent adenotonsillitis. HAdV C, B, and E were detectable in nearly 50% of the patients, with no association with the severity of airway obstruction, nor with the presence of recurrent tonsillitis, sleep apnea or otitis media with effusion (OME). Despite the higher rates of respiratory viral coinfections in patients with HAdV, the presence of other viruses, including DNA and RNA viruses, had no association with HAdV replication or shedding in secretions. Higher HAdV loads in adenoids showed a significant positive correlation with the presence of sleep apnea and the absence of OME. Although this study indicates that a significant proportion (~85%) of individuals with chronic adenotonsillar diseases have persistent nonproductive HAdV infection, including those by HAdV C, B, and E, epithelial and subepithelial cells in tonsils seem to be critical for HAdV C production and shedding in NPS in some patients, since viral antigen was detected in these regions by immunohistochemistry in four patients, all of which were also positive for HAdV mRNA detection. |*Virus Replication[MESH] |Adenoids/pathology/*virology[MESH] |Adenovirus Infections, Human/diagnosis/*virology[MESH] |Adenoviruses, Human/classification/isolation & purification/physiology[MESH] |Adolescent[MESH] |Child[MESH] |Child, Preschool[MESH] |Cross-Sectional Studies[MESH] |DNA, Viral/isolation & purification[MESH] |Female[MESH] |Humans[MESH] |Hypertrophy[MESH] |Infant[MESH] |Male[MESH] |Palatine Tonsil/pathology/*virology[MESH]Human adenovirus replication and persistence in hypertrophic adenoids (epmc).pdf DeepDyve Pubget Overpricing