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10.2174/1573406415666190225112950 http://scihub22266oqcxt.onion/10.2174/1573406415666190225112950 30799795!ä!30799795 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Med+Chem 2020 ; 16 (3): 368-384 Nephropedia Template TP {{tp|p=30799795|t=2020. Design, Synthesis, and Biological Evaluation of Novel C5-Modified Pyrimidine Ribofuranonucleosides as Potential Antitumor or/and Antiviral Agents |pdf=|usr=}}{{30799795}} gab.com Text Design, Synthesis, and Biological Evaluation of Novel C5-Modified Pyrimidine Ribofuranonucleosides as Potential Antitumor or/and Antiviral Agents JO: Med Chem http://www.kidney.de/pget.php?&tw=1&pmid=30799795 #FOAvip BACKGROUND: Nucleoside analogues are well-known antitumor, antiviral, and chemotherapeutic agents. Alterations on both their sugar and the heterocyclic parts may lead to significant changes in the spectrum of their biological activity and the degree of selective toxicity, as well as in their physicochemical properties. METHODS: C5-arylalkynyl-beta-D-ribofuranonucleosides 3-6, 3?-deoxy 12-15, 3?-deoxy-3?-C-methyl- beta-D-ribofurananucleosides 18-21 and 2?-deoxy-beta-D-ribofuranonucleosides 23-26 of uracil, were synthesized using a one-step Sonogashira reaction under microwave irradiation and subsequent deprotection. RESULTS: All newly synthesized nucleosides were tested for their antitumor or antiviral activity. Moderate cytostatic activity against cervix carcinoma (HeLa), murine leukemia (L1210) and human lymphocyte (CEM) tumor cell lines was displayed by the protected 3?-deoxy derivatives 12b,12c,12d, and the 3?-deoxy-3?-methyl 18a,18b,18c. The antiviral evaluation revealed appreciable activity against Coxsackie virus B4, Respiratory syncytial virus, Yellow Fever Virus and Human Coronavirus (229E) for the 3?-deoxy compounds 12b,14, and the 3?-deoxy-3?-methyl 18a,18c,18d, accompanied by low cytotoxicity. CONCLUSION: This report describes the total and facile synthesis of modified furanononucleosides of uracil, with alterations on both the sugar and the heterocyclic portions. Compounds 12b,14 and 18a,c,d showed noticeable antiviral activity against a series of RNA viruses and merit further biological and structural optimization investigations. Twit Text FOAVip Design, Synthesis, and Biological Evaluation of Novel C5-Modified Pyrimidine Ribofuranonucleosides as Potential Antitumor or/and Antiviral Agents ????Med Chem http://www.kidney.de/pget.php?&tw=1&pmid=30799795 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=30799795 #FOAvip English Wikipedia <ref>{{Cite pmid|30799795}}</ref> Design, Synthesis, and Biological Evaluation of Novel C5-Modified Pyrimidine Ribofuranonucleosides as Potential Antitumor or/and Antiviral Agents #MMPMID30799795 Kollatos N; Mitsos C; Manta S; Tzioumaki N; Giannakas C; Alexouli T; Panagiotopoulou A; Schols D; Andrei G; Komiotis D Med Chem 2020[]; 16 (3): 368-384 PMID30799795show ga BACKGROUND: Nucleoside analogues are well-known antitumor, antiviral, and chemotherapeutic agents. Alterations on both their sugar and the heterocyclic parts may lead to significant changes in the spectrum of their biological activity and the degree of selective toxicity, as well as in their physicochemical properties. METHODS: C5-arylalkynyl-beta-D-ribofuranonucleosides 3-6, 3?-deoxy 12-15, 3?-deoxy-3?-C-methyl- beta-D-ribofurananucleosides 18-21 and 2?-deoxy-beta-D-ribofuranonucleosides 23-26 of uracil, were synthesized using a one-step Sonogashira reaction under microwave irradiation and subsequent deprotection. RESULTS: All newly synthesized nucleosides were tested for their antitumor or antiviral activity. Moderate cytostatic activity against cervix carcinoma (HeLa), murine leukemia (L1210) and human lymphocyte (CEM) tumor cell lines was displayed by the protected 3?-deoxy derivatives 12b,12c,12d, and the 3?-deoxy-3?-methyl 18a,18b,18c. The antiviral evaluation revealed appreciable activity against Coxsackie virus B4, Respiratory syncytial virus, Yellow Fever Virus and Human Coronavirus (229E) for the 3?-deoxy compounds 12b,14, and the 3?-deoxy-3?-methyl 18a,18c,18d, accompanied by low cytotoxicity. CONCLUSION: This report describes the total and facile synthesis of modified furanononucleosides of uracil, with alterations on both the sugar and the heterocyclic portions. Compounds 12b,14 and 18a,c,d showed noticeable antiviral activity against a series of RNA viruses and merit further biological and structural optimization investigations. |*Drug Design[MESH] |Animals[MESH] |Antineoplastic Agents/*chemical synthesis/chemistry/*pharmacology[MESH] |Antiviral Agents/*chemical synthesis/chemistry/*pharmacology[MESH] |Cell Proliferation/drug effects[MESH] |Chemistry Techniques, Synthetic[MESH] |HeLa Cells[MESH] |Humans[MESH] |Mice[MESH]Design, Synthesis, and Biological Evaluation of Novel C5-Modified Pyri(epmc).pdf DeepDyve Pubget Overpricing