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10.1073/pnas.1810633116 http://scihub22266oqcxt.onion/10.1073/pnas.1810633116 30770447!6410795!30770447     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Proc+Natl+Acad+Sci+U+S+A 2019 ; 116 (10): 4706-4715 Nephropedia Template TP {{tp|p=30770447|t=2019. TRPM7 is the central gatekeeper of intestinal mineral absorption essential for postnatal survival |pdf=|usr=}}{{30770447}} gab.com Text TRPM7 is the central gatekeeper of intestinal mineral absorption essential for postnatal survival JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=30770447 #FOAvip Zn(2+), Mg(2+), and Ca(2+) are essential minerals required for a plethora of metabolic processes and signaling pathways. Different categories of cation-selective channels and transporters are therefore required to tightly control the cellular levels of individual metals in a cell-specific manner. However, the mechanisms responsible for the organismal balance of these essential minerals are poorly understood. Herein, we identify a central and indispensable role of the channel-kinase TRPM7 for organismal mineral homeostasis. The function of TRPM7 was assessed by single-channel analysis of TRPM7, phenotyping of TRPM7-deficient cells in conjunction with metabolic profiling of mice carrying kidney- and intestine-restricted null mutations in Trpm7 and animals with a global "kinase-dead" point mutation in the gene. The TRPM7 channel reconstituted in lipid bilayers displayed a similar permeability to Zn(2+) and Mg(2+) Consistently, we found that endogenous TRPM7 regulates the total content of Zn(2+) and Mg(2+) in cultured cells. Unexpectedly, genetic inactivation of intestinal rather than kidney TRPM7 caused profound deficiencies specifically of Zn(2+), Mg(2+), and Ca(2+) at the organismal level, a scenario incompatible with early postnatal growth and survival. In contrast, global ablation of TRPM7 kinase activity did not affect mineral homeostasis, reinforcing the importance of the channel activity of TRPM7. Finally, dietary Zn(2+) and Mg(2+) fortifications significantly extended the survival of offspring lacking intestinal TRPM7. Hence, the organismal balance of divalent cations critically relies on one common gatekeeper, the intestinal TRPM7 channel. Twit Text FOAVip TRPM7 is the central gatekeeper of intestinal mineral absorption essential for postnatal survival ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=30770447 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=30770447 #FOAvip English Wikipedia <ref>{{Cite pmid|30770447}}</ref> TRPM7 is the central gatekeeper of intestinal mineral absorption essential for postnatal survival #MMPMID30770447 Mittermeier L; Demirkhanyan L; Stadlbauer B; Breit A; Recordati C; Hilgendorff A; Matsushita M; Braun A; Simmons DG; Zakharian E; Gudermann T; Chubanov V Proc Natl Acad Sci U S A 2019[Mar]; 116 (10): 4706-4715 PMID30770447show ga Zn(2+), Mg(2+), and Ca(2+) are essential minerals required for a plethora of metabolic processes and signaling pathways. Different categories of cation-selective channels and transporters are therefore required to tightly control the cellular levels of individual metals in a cell-specific manner. However, the mechanisms responsible for the organismal balance of these essential minerals are poorly understood. Herein, we identify a central and indispensable role of the channel-kinase TRPM7 for organismal mineral homeostasis. The function of TRPM7 was assessed by single-channel analysis of TRPM7, phenotyping of TRPM7-deficient cells in conjunction with metabolic profiling of mice carrying kidney- and intestine-restricted null mutations in Trpm7 and animals with a global "kinase-dead" point mutation in the gene. The TRPM7 channel reconstituted in lipid bilayers displayed a similar permeability to Zn(2+) and Mg(2+) Consistently, we found that endogenous TRPM7 regulates the total content of Zn(2+) and Mg(2+) in cultured cells. Unexpectedly, genetic inactivation of intestinal rather than kidney TRPM7 caused profound deficiencies specifically of Zn(2+), Mg(2+), and Ca(2+) at the organismal level, a scenario incompatible with early postnatal growth and survival. In contrast, global ablation of TRPM7 kinase activity did not affect mineral homeostasis, reinforcing the importance of the channel activity of TRPM7. Finally, dietary Zn(2+) and Mg(2+) fortifications significantly extended the survival of offspring lacking intestinal TRPM7. Hence, the organismal balance of divalent cations critically relies on one common gatekeeper, the intestinal TRPM7 channel. |Animals[MESH] |Calcium/metabolism[MESH] |Gene Knockout Techniques[MESH] |Homeostasis[MESH] |Intestinal Mucosa/*metabolism[MESH] |Kidney/metabolism[MESH] |Magnesium/metabolism[MESH] |Mice[MESH] |Mice, Knockout[MESH] |Minerals/*metabolism[MESH] |TRPM Cation Channels/genetics/*metabolism[MESH]TRPM7 is the central gatekeeper of intestinal mineral absorption essen(epmc).pdf DeepDyve Pubget Overpricing