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10.1038/s41598-018-38351-3 http://scihub22266oqcxt.onion/10.1038/s41598-018-38351-3 30742025!6370757!30742025     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=30742025&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Rep 2019 ; 9 (1): 1770 Nephropedia Template TP {{tp|p=30742025|t=2019. Diabetes-induced hypomagnesemia is not modulated by metformin treatment in mice |pdf=|usr=}}{{30742025}} gab.com Text Diabetes-induced hypomagnesemia is not modulated by metformin treatment in mice JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=30742025 #FOAvip Approximately 30% of patients with type 2 diabetes mellitus (T2D) have hypomagnesemia (blood magnesium (Mg(2+)) concentration <0.7 mmol/L). In T2D patients, treatment with metformin is associated with reduced blood Mg(2+) levels. To investigate how T2D and metformin affect Mg(2+) homeostasis db/m and db/db mice were treated with metformin or placebo. Mice were housed in metabolic cages to measure food and water intake, and to collect urine and feces. Serum and urinary Mg(2+) concentrations were determined and mRNA expression of magnesiotropic genes was determined in kidney and distal colon using RT-qPCR. Db/db mice had significantly lower serum Mg(2+) levels than db/m mice. Mild hypermagnesuria was observed in the db/db mice at two weeks, but not at four weeks. Metformin-treatment had no effect on the serum Mg(2+) concentration and on the urinary Mg(2+) excretion. Both in kidney and distal colon of db/db mice, there was a compensatory upregulation in the mRNA expression of magnesiotropic genes, such as transient receptor potential melastatin 6 (Trpm6), whereas metformin treatment did not affect gene expression levels. In conclusion, we show that T2D causes hypomagnesemia and that metformin treatment has no effect on Mg(2+) homeostasis in mice. Twit Text FOAVip Diabetes-induced hypomagnesemia is not modulated by metformin treatment in mice ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=30742025 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=30742025 #FOAvip English Wikipedia <ref>{{Cite pmid|30742025}}</ref> Diabetes-induced hypomagnesemia is not modulated by metformin treatment in mice #MMPMID30742025 Kurstjens S; Bouras H; Overmars-Bos C; Kebieche M; Bindels RJM; Hoenderop JGJ; de Baaij JHF Sci Rep 2019[Feb]; 9 (1): 1770 PMID30742025show ga Approximately 30% of patients with type 2 diabetes mellitus (T2D) have hypomagnesemia (blood magnesium (Mg(2+)) concentration <0.7 mmol/L). In T2D patients, treatment with metformin is associated with reduced blood Mg(2+) levels. To investigate how T2D and metformin affect Mg(2+) homeostasis db/m and db/db mice were treated with metformin or placebo. Mice were housed in metabolic cages to measure food and water intake, and to collect urine and feces. Serum and urinary Mg(2+) concentrations were determined and mRNA expression of magnesiotropic genes was determined in kidney and distal colon using RT-qPCR. Db/db mice had significantly lower serum Mg(2+) levels than db/m mice. Mild hypermagnesuria was observed in the db/db mice at two weeks, but not at four weeks. Metformin-treatment had no effect on the serum Mg(2+) concentration and on the urinary Mg(2+) excretion. Both in kidney and distal colon of db/db mice, there was a compensatory upregulation in the mRNA expression of magnesiotropic genes, such as transient receptor potential melastatin 6 (Trpm6), whereas metformin treatment did not affect gene expression levels. In conclusion, we show that T2D causes hypomagnesemia and that metformin treatment has no effect on Mg(2+) homeostasis in mice. |Animals[MESH] |Biomarkers[MESH] |Diabetes Complications/*blood/drug therapy[MESH] |Diabetes Mellitus, Type 2/*complications/drug therapy[MESH] |Disease Models, Animal[MESH] |Gene Expression[MESH] |Hypoglycemic Agents/*pharmacology/therapeutic use[MESH] |Kidney/drug effects/metabolism[MESH] |Magnesium/*blood[MESH] |Metformin/*pharmacology/therapeutic use[MESH] |Mice[MESH] |Mice, Transgenic[MESH]Diabetes-induced hypomagnesemia is not modulated by metformin treatmen(epmc).pdf DeepDyve Pubget Overpricing