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10.1111/cas.13968 http://scihub22266oqcxt.onion/10.1111/cas.13968 30737998/?report=reader!6447855!30737998     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cancer+Sci 2019 ; 110 (4): 1464-1479 Nephropedia Template TP {{tp|p=30737998|t=2019. Comprehensive assay for the molecular profiling of cancer by target enrichment from formalin-fixed paraffin-embedded specimens |pdf=|usr=}}{{30737998}} gab.com Text Comprehensive assay for the molecular profiling of cancer by target enrichment from formalin-fixed paraffin-embedded specimens JO: Cancer Sci http://www.kidney.de/pget.php?&tw=1&pmid=30737998 #FOAvip Tumor molecular profiling is becoming a standard of care for patients with cancer, but the optimal platform for cancer sequencing remains undetermined. We established a comprehensive assay, the Todai OncoPanel (TOP), which consists of DNA and RNA hybridization capture-based next-generation sequencing panels. A novel method for target enrichment, named the junction capture method, was developed for the RNA panel to accurately and cost-effectively detect 365 fusion genes as well as aberrantly spliced transcripts. The TOP RNA panel can also measure the expression profiles of an additional 109 genes. The TOP DNA panel was developed to detect single nucleotide variants and insertions/deletions for 464 genes, to calculate tumor mutation burden and microsatellite instability status, and to infer chromosomal copy number. Clinically relevant somatic mutations were identified in 32.2% (59/183) of patients by prospective TOP testing, signifying the clinical utility of TOP for providing personalized medicine to cancer patients. Twit Text FOAVip Comprehensive assay for the molecular profiling of cancer by target enrichment from formalin-fixed paraffin-embedded specimens ????Cancer Sci http://www.kidney.de/pget.php?&tw=1&pmid=30737998 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=30737998 #FOAvip English Wikipedia <ref>{{Cite pmid|30737998}}</ref> Comprehensive assay for the molecular profiling of cancer by target enrichment from formalin-fixed paraffin-embedded specimens #MMPMID30737998 Kohsaka S; Tatsuno K; Ueno T; Nagano M; Shinozaki-Ushiku A; Ushiku T; Takai D; Ikegami M; Kobayashi H; Kage H; Ando M; Hata K; Ueda H; Yamamoto S; Kojima S; Oseto K; Akaike K; Suehara Y; Hayashi T; Saito T; Takahashi F; Takahashi K; Takamochi K; Suzuki K; Nagayama S; Oda Y; Mimori K; Ishihara S; Yatomi Y; Nagase T; Nakajima J; Tanaka S; Fukayama M; Oda K; Nangaku M; Miyazono K; Miyagawa K; Aburatani H; Mano H Cancer Sci 2019[Apr]; 110 (4): 1464-1479 PMID30737998show ga Tumor molecular profiling is becoming a standard of care for patients with cancer, but the optimal platform for cancer sequencing remains undetermined. We established a comprehensive assay, the Todai OncoPanel (TOP), which consists of DNA and RNA hybridization capture-based next-generation sequencing panels. A novel method for target enrichment, named the junction capture method, was developed for the RNA panel to accurately and cost-effectively detect 365 fusion genes as well as aberrantly spliced transcripts. The TOP RNA panel can also measure the expression profiles of an additional 109 genes. The TOP DNA panel was developed to detect single nucleotide variants and insertions/deletions for 464 genes, to calculate tumor mutation burden and microsatellite instability status, and to infer chromosomal copy number. Clinically relevant somatic mutations were identified in 32.2% (59/183) of patients by prospective TOP testing, signifying the clinical utility of TOP for providing personalized medicine to cancer patients. |*Gene Expression Profiling[MESH] |*Transcriptome[MESH] |Alternative Splicing[MESH] |Biomarkers, Tumor[MESH] |Biopsy[MESH] |Gene Expression Regulation, Neoplastic[MESH] |Humans[MESH] |Immunohistochemistry[MESH] |Neoplasms/diagnosis/*genetics/metabolism[MESH] |Oncogene Proteins, Fusion/genetics[MESH]Comprehensive assay for the molecular profiling of cancer by target en(epmc).pdf DeepDyve Pubget Overpricing