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10.1007/s10787-019-00568-7 http://scihub22266oqcxt.onion/10.1007/s10787-019-00568-7 30721372!ä!30721372 Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=30721372&cmd=llinks): Failed to open stream: HTTP request failed! 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Magnesium sulfate inhibits binding of lipopolysaccharide to THP-1 cells by reducing expression of cluster of differentiation 14 |pdf=|usr=}}{{30721372}} gab.com Text Magnesium sulfate inhibits binding of lipopolysaccharide to THP-1 cells by reducing expression of cluster of differentiation 14 JO: Inflammopharmacology http://www.kidney.de/pget.php?&tw=1&pmid=30721372 #FOAvip We investigated effects of magnesium sulfate (MgSO(4)) on modulating lipopolysaccharide (LPS)-macrophage binding and cluster of differentiation 14 (CD14) expression. Flow cytometry data revealed that the mean levels of LPS-macrophage binding and membrane-bound CD14 expression (mCD14) in differentiated THP-1 cells (a human monocytic cell line) treated with LPS plus MgSO(4) (the LPS + M group) decreased by 28.2% and 25.3% compared with those THP-1 cells treated with LPS only (the LPS group) (P < 0.001 and P = 0.037), indicating that MgSO(4) significantly inhibits LPS-macrophage binding and mCD14 expression. Notably, these effects of MgSO(4) were counteracted by L-type calcium channel activation. Moreover, the mean level of soluble CD14 (sCD14; proteolytic cleavage product of CD14) in the LPS + M group was 25.6% higher than in the LPS group (P < 0.001), indicating that MgSO(4) significantly enhances CD14 proteolytic cleavage. Of note, serine protease inhibition mitigated effects of MgSO(4) on both decreasing mCD14 and increasing sCD14. In conclusion, MgSO(4) inhibits LPS-macrophage binding through reducing CD14 expression. The mechanisms may involve antagonizing L-type calcium channels and activating serine proteases. Twit Text FOAVip Magnesium sulfate inhibits binding of lipopolysaccharide to THP-1 cells by reducing expression of cluster of differentiation 14 ????Inflammopharmacology http://www.kidney.de/pget.php?&tw=1&pmid=30721372 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=30721372 #FOAvip English Wikipedia <ref>{{Cite pmid|30721372}}</ref> Magnesium sulfate inhibits binding of lipopolysaccharide to THP-1 cells by reducing expression of cluster of differentiation 14 #MMPMID30721372 Chang YY; Lin TY; Kao MC; Chen TY; Cheng CF; Wong CS; Huang CJ Inflammopharmacology 2019[Apr]; 27 (2): 249-260 PMID30721372show ga We investigated effects of magnesium sulfate (MgSO(4)) on modulating lipopolysaccharide (LPS)-macrophage binding and cluster of differentiation 14 (CD14) expression. Flow cytometry data revealed that the mean levels of LPS-macrophage binding and membrane-bound CD14 expression (mCD14) in differentiated THP-1 cells (a human monocytic cell line) treated with LPS plus MgSO(4) (the LPS + M group) decreased by 28.2% and 25.3% compared with those THP-1 cells treated with LPS only (the LPS group) (P < 0.001 and P = 0.037), indicating that MgSO(4) significantly inhibits LPS-macrophage binding and mCD14 expression. Notably, these effects of MgSO(4) were counteracted by L-type calcium channel activation. Moreover, the mean level of soluble CD14 (sCD14; proteolytic cleavage product of CD14) in the LPS + M group was 25.6% higher than in the LPS group (P < 0.001), indicating that MgSO(4) significantly enhances CD14 proteolytic cleavage. Of note, serine protease inhibition mitigated effects of MgSO(4) on both decreasing mCD14 and increasing sCD14. In conclusion, MgSO(4) inhibits LPS-macrophage binding through reducing CD14 expression. The mechanisms may involve antagonizing L-type calcium channels and activating serine proteases. |Cell Differentiation/drug effects[MESH] |Cell Line[MESH] |Humans[MESH] |Lipopolysaccharide Receptors/*metabolism[MESH] |Lipopolysaccharides/*pharmacology[MESH] |Macrophages/drug effects/metabolism[MESH] |Magnesium Sulfate/*pharmacology[MESH] |Monocytes/drug effects/metabolism[MESH]Magnesium sulfate inhibits binding of lipopolysaccharide to THP-1 cell(epmc).pdf DeepDyve Pubget Overpricing