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10.1007/s10517-019-04350-1

http://scihub22266oqcxt.onion/10.1007/s10517-019-04350-1
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30627911!ä!30627911

suck abstract from ncbi


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pmid30627911      Bull+Exp+Biol+Med 2019 ; 166 (3): 358-363
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  • Changes in the Structure of Mouse Kidney in the Acute Period after Infection with Influenza Viruses A/H5N1 and A/H1N1 #MMPMID30627911
  • Shkurupy VA; Potapova OV; Mezhevalova AS; Cherdantseva LA; Kovner AV; Shestopalov AM
  • Bull Exp Biol Med 2019[Jan]; 166 (3): 358-363 PMID30627911show ga
  • Changes in the kidney structure in outbred and inbred male BALB/c mice were analyzed in the acute period after infection with influenza viruses A/H5N1 (10 MLD(50); 10 days) and A/H1N1 (1 MLD(50); 30 days). Antibodies to influenza viruses of both strains were most often expressed by endothelial cells of the glomeruli and arterioles and were rarely expressed by mesangiocytes and tubule epithelial cells. In the kidney, destructive processes induced by viruses and by ischemia due to massive blood vessel thrombosis. Mesangiocytes expressed factors, indicating that they could be qualified as M1 and M2 macrophages. Kidney destruction was more significant after infection of mice with the A/H5N1 virus, but in both experiments cell infiltrates were actually absent, probably due to blood vessel thrombosis and limited possibility of migration of mononuclear phagocytes and lymphocytes to the kidney.
  • |Animals[MESH]
  • |Animals, Outbred Strains[MESH]
  • |Antigens, Viral/genetics/immunology[MESH]
  • |Endothelial Cells/*pathology/virology[MESH]
  • |Gene Expression[MESH]
  • |Host-Pathogen Interactions[MESH]
  • |Influenza A Virus, H1N1 Subtype/genetics/growth & development/*pathogenicity[MESH]
  • |Influenza A Virus, H5N1 Subtype/genetics/growth & development/*pathogenicity[MESH]
  • |Interleukin-16/genetics/immunology[MESH]
  • |Kidney Glomerulus/blood supply/*pathology/virology[MESH]
  • |Lipopolysaccharide Receptors/genetics/immunology[MESH]
  • |Macrophages/*pathology/virology[MESH]
  • |Male[MESH]
  • |Mesangial Cells/*pathology/virology[MESH]
  • |Mice[MESH]
  • |Mice, Inbred BALB C[MESH]
  • |Nitric Oxide Synthase Type II/genetics/immunology[MESH]
  • |Orthomyxoviridae Infections/genetics/immunology/*pathology/virology[MESH]
  • |Transforming Growth Factor beta1/genetics/immunology[MESH]


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