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10.1186/s40478-018-0647-5

http://scihub22266oqcxt.onion/10.1186/s40478-018-0647-5
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suck abstract from ncbi


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pmid30626447      Acta+Neuropathol+Commun 2019 ; 7 (1): 6
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  • Low-level blast exposure disrupts gliovascular and neurovascular connections and induces a chronic vascular pathology in rat brain #MMPMID30626447
  • Gama Sosa MA; De Gasperi R; Perez Garcia GS; Perez GM; Searcy C; Vargas D; Spencer A; Janssen PL; Tschiffely AE; McCarron RM; Ache B; Manoharan R; Janssen WG; Tappan SJ; Hanson RW; Gandy S; Hof PR; Ahlers ST; Elder GA
  • Acta Neuropathol Commun 2019[Jan]; 7 (1): 6 PMID30626447show ga
  • Much concern exists over the role of blast-induced traumatic brain injury (TBI) in the chronic cognitive and mental health problems that develop in veterans and active duty military personnel. The brain vasculature is particularly sensitive to blast injury. The aim of this study was to characterize the evolving molecular and histologic alterations in the neurovascular unit induced by three repetitive low-energy blast exposures (3 x 74.5 kPa) in a rat model mimicking human mild TBI or subclinical blast exposure. High-resolution two-dimensional differential gel electrophoresis (2D-DIGE) and matrix-assisted laser desorption/ionization (MALDI) mass spectrometry of purified brain vascular fractions from blast-exposed animals 6 weeks post-exposure showed decreased levels of vascular-associated glial fibrillary acidic protein (GFAP) and several neuronal intermediate filament proteins (alpha-internexin and the low, middle, and high molecular weight neurofilament subunits). Loss of these proteins suggested that blast exposure disrupts gliovascular and neurovascular interactions. Electron microscopy confirmed blast-induced effects on perivascular astrocytes including swelling and degeneration of astrocytic endfeet in the brain cortical vasculature. Because the astrocyte is a major sensor of neuronal activity and regulator of cerebral blood flow, structural disruption of gliovascular integrity within the neurovascular unit should impair cerebral autoregulation. Disrupted neurovascular connections to pial and parenchymal blood vessels might also affect brain circulation. Blast exposures also induced structural and functional alterations in the arterial smooth muscle layer. Interestingly, by 8 months after blast exposure, GFAP and neuronal intermediate filament expression had recovered to control levels in isolated brain vascular fractions. However, despite this recovery, a widespread vascular pathology was still apparent at 10 months after blast exposure histologically and on micro-computed tomography scanning. Thus, low-level blast exposure disrupts gliovascular and neurovascular connections while inducing a chronic vascular pathology.
  • |Animals[MESH]
  • |Astrocytes/metabolism/*pathology[MESH]
  • |Brain Concussion/metabolism/*pathology[MESH]
  • |Brain/*blood supply/metabolism/*pathology[MESH]
  • |Disease Models, Animal[MESH]
  • |Male[MESH]
  • |Neurons/metabolism/*pathology[MESH]


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