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10.1016/j.bmc.2018.12.033 http://scihub22266oqcxt.onion/10.1016/j.bmc.2018.12.033 30617018!ä!30617018 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 286.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 286.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 286.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Bioorg+Med+Chem 2019 ; 27 (3): 516-524 Nephropedia Template TP {{tp|p=30617018|t=2019. Magnesium isoglycyrrhizinate suppresses LPS-induced inflammation and oxidative stress through inhibiting NF-kappaB and MAPK pathways in RAW264 7 cells |pdf=|usr=}}{{30617018}} gab.com Text Magnesium isoglycyrrhizinate suppresses LPS-induced inflammation and oxidative stress through inhibiting NF-kappaB and MAPK pathways in RAW264 7 cells JO: Bioorg Med Chem http://www.kidney.de/pget.php?&tw=1&pmid=30617018 #FOAvip Magnesium Isoglycyrrhizinate (MgIG), a novel molecular compound extracted from licorice root, has exhibited greater anti-inflammatory activity and hepatic protection than glycyrrhizin and beta-glycyrrhizic acid. In this study, we investigated the anti-inflammatory effect and the potential mechanism of MgIG on Lipopolysaccharide (LPS)-treated RAW264.7 cells. MgIG down-regulated LPS-induced pro-inflammatory mediators and enzymes in LPS-treated RAW264.7 cells, including TNF-alpha, IL-6, IL-1beta, IL-8, NO and iNOS. The generation of reactive oxygen species (ROS) in LPS-treated RAW264.7 cells was also reduced. MgIG attenuated NF-kappaB translocation by inhibiting IKK phosphorylation and IkappaB-alpha degradation. Simultaneously, MgIG also inhibited LPS-induced activation of MAPKs, including p38, JNK and ERK1/2. Taken together, these results suggest that MgIG suppresses inflammation by blocking NF-kappaB and MAPK signaling pathways, and down-regulates ROS generation and inflammatory mediators. Twit Text FOAVip Magnesium isoglycyrrhizinate suppresses LPS-induced inflammation and oxidative stress through inhibiting NF-kappaB and MAPK pathways in RAW264 7 cells ????Bioorg Med Chem http://www.kidney.de/pget.php?&tw=1&pmid=30617018 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=30617018 #FOAvip English Wikipedia <ref>{{Cite pmid|30617018}}</ref> Magnesium isoglycyrrhizinate suppresses LPS-induced inflammation and oxidative stress through inhibiting NF-kappaB and MAPK pathways in RAW264 7 cells #MMPMID30617018 Xie C; Li X; Zhu J; Wu J; Geng S; Zhong C Bioorg Med Chem 2019[Feb]; 27 (3): 516-524 PMID30617018show ga Magnesium Isoglycyrrhizinate (MgIG), a novel molecular compound extracted from licorice root, has exhibited greater anti-inflammatory activity and hepatic protection than glycyrrhizin and beta-glycyrrhizic acid. In this study, we investigated the anti-inflammatory effect and the potential mechanism of MgIG on Lipopolysaccharide (LPS)-treated RAW264.7 cells. MgIG down-regulated LPS-induced pro-inflammatory mediators and enzymes in LPS-treated RAW264.7 cells, including TNF-alpha, IL-6, IL-1beta, IL-8, NO and iNOS. The generation of reactive oxygen species (ROS) in LPS-treated RAW264.7 cells was also reduced. MgIG attenuated NF-kappaB translocation by inhibiting IKK phosphorylation and IkappaB-alpha degradation. Simultaneously, MgIG also inhibited LPS-induced activation of MAPKs, including p38, JNK and ERK1/2. Taken together, these results suggest that MgIG suppresses inflammation by blocking NF-kappaB and MAPK signaling pathways, and down-regulates ROS generation and inflammatory mediators. |Animals[MESH] |Anti-Inflammatory Agents, Non-Steroidal/*pharmacology[MESH] |Cells, Cultured[MESH] |Cytokines/antagonists & inhibitors/metabolism[MESH] |Dose-Response Relationship, Drug[MESH] |Inflammation/drug therapy/metabolism[MESH] |Lipopolysaccharides/*antagonists & inhibitors/pharmacology[MESH] |MAP Kinase Signaling System/drug effects[MESH] |Mice[MESH] |Mitogen-Activated Protein Kinases/*antagonists & inhibitors/metabolism[MESH] |Molecular Structure[MESH] |NF-kappa B/*antagonists & inhibitors/metabolism[MESH] |Nitric Oxide/antagonists & inhibitors/biosynthesis[MESH] |RAW 264.7 Cells[MESH] |Reactive Oxygen Species/antagonists & inhibitors/metabolism[MESH] |Saponins/*pharmacology[MESH] |Structure-Activity Relationship[MESH]Magnesium isoglycyrrhizinate suppresses LPS-induced inflammation and o(epmc).pdf DeepDyve Pubget Overpricing