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10.1016/j.virol.2018.11.016 http://scihub22266oqcxt.onion/10.1016/j.virol.2018.11.016 30580124!ä!30580124 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Virology 2019 ; 528 (ä): 80-88 Nephropedia Template TP {{tp|p=30580124|t=2019. heme oxygenase-1 agonist CoPP suppresses influenza virus replication through IRF3-mediated generation of IFN-alpha/beta |pdf=|usr=}}{{30580124}} gab.com Text heme oxygenase-1 agonist CoPP suppresses influenza virus replication through IRF3-mediated generation of IFN-alpha/beta JO: Virology http://www.kidney.de/pget.php?&tw=1&pmid=30580124 #FOAvip The innate immunity plays an essential role in defending infection of Influenza A virus (IAV). The regulatory effect of heme oxygenase-1 (HO-1), a cytoprotective enzyme, on innate immunity has been revealed. In this study, we aim to confirm the antiviral effect of CoPP (Cobaltic Protoporphyrin IX Chloride), a potent HO-1 inducer on IAV infection and elucidate the possible mechanism of HO-1-mediated host innate immune responses. Our results show that CoPP exhibits broad-spectrum antiviral activities against IAV. Furthermore, CoPP attenuates IAV replication through inducing type I IFNs response, not depending on HO-1 enzymatic activity. We also provide direct evidence that HO-1-mediated type I IFN response activation is largely due to its interaction with IRF3, which then promotes IRF3 phosphorylation and nuclear translocation. These results suggest that HO-1 agonist CoPP suppresses IAV replication through IRF3-mediated generation of IFN-alpha/beta. Thus, therapeutic induction of HO-1 might be a promising strategy to combat IAV epidemics. Twit Text FOAVip heme oxygenase-1 agonist CoPP suppresses influenza virus replication through IRF3-mediated generation of IFN-alpha/beta ????Virology http://www.kidney.de/pget.php?&tw=1&pmid=30580124 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=30580124 #FOAvip English Wikipedia <ref>{{Cite pmid|30580124}}</ref> heme oxygenase-1 agonist CoPP suppresses influenza virus replication through IRF3-mediated generation of IFN-alpha/beta #MMPMID30580124 Ma LL; Zhang P; Wang HQ; Li YF; Hu J; Jiang JD; Li YH Virology 2019[Feb]; 528 (ä): 80-88 PMID30580124show ga The innate immunity plays an essential role in defending infection of Influenza A virus (IAV). The regulatory effect of heme oxygenase-1 (HO-1), a cytoprotective enzyme, on innate immunity has been revealed. In this study, we aim to confirm the antiviral effect of CoPP (Cobaltic Protoporphyrin IX Chloride), a potent HO-1 inducer on IAV infection and elucidate the possible mechanism of HO-1-mediated host innate immune responses. Our results show that CoPP exhibits broad-spectrum antiviral activities against IAV. Furthermore, CoPP attenuates IAV replication through inducing type I IFNs response, not depending on HO-1 enzymatic activity. We also provide direct evidence that HO-1-mediated type I IFN response activation is largely due to its interaction with IRF3, which then promotes IRF3 phosphorylation and nuclear translocation. These results suggest that HO-1 agonist CoPP suppresses IAV replication through IRF3-mediated generation of IFN-alpha/beta. Thus, therapeutic induction of HO-1 might be a promising strategy to combat IAV epidemics. |Animals[MESH] |Dogs[MESH] |Enzyme Activators/*pharmacology[MESH] |Gene Expression Regulation/immunology[MESH] |Heme Oxygenase-1/genetics/*immunology[MESH] |Immunity, Innate[MESH] |Influenza A virus/*drug effects[MESH] |Interferon Regulatory Factor-3/*immunology[MESH] |Interferon-alpha/immunology[MESH] |Interferon-beta/immunology[MESH] |Madin Darby Canine Kidney Cells[MESH] |Mice[MESH] |Protoporphyrins/*pharmacology[MESH] |RAW 264.7 Cells[MESH]heme oxygenase-1 agonist CoPP suppresses influenza virus replication t(epmc).pdf DeepDyve Pubget Overpricing