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10.1007/s10741-018-9757-1 http://scihub22266oqcxt.onion/10.1007/s10741-018-9757-1 30565021!6394573!30565021     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Heart+Fail+Rev 2019 ; 24 (2): 167-176 Nephropedia Template TP {{tp|p=30565021|t=2019. Practical guidance on the use of sacubitril/valsartan for heart failure |pdf=|usr=}}{{30565021}} gab.com Text Practical guidance on the use of sacubitril/valsartan for heart failure JO: Heart Fail Rev http://www.kidney.de/pget.php?&tw=1&pmid=30565021 #FOAvip Sacubitril/valsartan is a first-in-class angiotensin receptor-neprilysin inhibitor (ARNI) that has been recommended in clinical practice guidelines to reduce morbidity and mortality in patients with chronic, symptomatic heart failure (HF) with reduced ejection fraction (HFrEF). This review provides an overview of ARNI therapy, proposes strategies to improve the implementation of sacubitril/valsartan in clinical practice, and provides clinicians with evidence-based, practical guidance on the use of sacubitril/valsartan in patients with HFrEF. Despite evidence demonstrating the benefits of ARNI therapy over standard of care, only a fraction of eligible patients takes sacubitril/valsartan. Barriers preventing the prescription of sacubitril/valsartan in eligible patients may include practitioners' unfamiliarity with ARNIs, safety concerns, and payer reimbursement issues. The optimal implementation of sacubitril/valsartan in clinical practice has the potential to reduce the overall burden of HF. Throughout this review, we describe our experience with sacubitril/valsartan, including strategies for the management of adverse events and common patient concerns. In addition, a strategy for the gradual introduction of sacubitril/valsartan using a treatment sequence scheme is proposed. Twit Text FOAVip Practical guidance on the use of sacubitril/valsartan for heart failure ????Heart Fail Rev http://www.kidney.de/pget.php?&tw=1&pmid=30565021 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=30565021 #FOAvip English Wikipedia <ref>{{Cite pmid|30565021}}</ref> Practical guidance on the use of sacubitril/valsartan for heart failure #MMPMID30565021 Sauer AJ; Cole R; Jensen BC; Pal J; Sharma N; Yehya A; Vader J Heart Fail Rev 2019[Mar]; 24 (2): 167-176 PMID30565021show ga Sacubitril/valsartan is a first-in-class angiotensin receptor-neprilysin inhibitor (ARNI) that has been recommended in clinical practice guidelines to reduce morbidity and mortality in patients with chronic, symptomatic heart failure (HF) with reduced ejection fraction (HFrEF). This review provides an overview of ARNI therapy, proposes strategies to improve the implementation of sacubitril/valsartan in clinical practice, and provides clinicians with evidence-based, practical guidance on the use of sacubitril/valsartan in patients with HFrEF. Despite evidence demonstrating the benefits of ARNI therapy over standard of care, only a fraction of eligible patients takes sacubitril/valsartan. Barriers preventing the prescription of sacubitril/valsartan in eligible patients may include practitioners' unfamiliarity with ARNIs, safety concerns, and payer reimbursement issues. The optimal implementation of sacubitril/valsartan in clinical practice has the potential to reduce the overall burden of HF. Throughout this review, we describe our experience with sacubitril/valsartan, including strategies for the management of adverse events and common patient concerns. In addition, a strategy for the gradual introduction of sacubitril/valsartan using a treatment sequence scheme is proposed. |Aged[MESH] |Aged, 80 and over[MESH] |Aminobutyrates/adverse effects/*therapeutic use[MESH] |Angiotensin Receptor Antagonists/adverse effects/*therapeutic use[MESH] |Biphenyl Compounds[MESH] |Comorbidity[MESH] |Cost of Illness[MESH] |Drug Combinations[MESH] |Evidence-Based Medicine[MESH] |Heart Failure/*drug therapy/mortality/physiopathology[MESH] |Humans[MESH] |Middle Aged[MESH] |Morbidity/trends[MESH] |Mortality/trends[MESH] |Practice Guidelines as Topic[MESH] |Stroke Volume/drug effects[MESH] |Tetrazoles/adverse effects/*therapeutic use[MESH] |Treatment Outcome[MESH] |Valsartan[MESH]Practical guidance on the use of sacubitril/valsartan for heart failur(epmc).pdf DeepDyve Pubget Overpricing