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10.1021/acsomega.8b01754 http://scihub22266oqcxt.onion/10.1021/acsomega.8b01754 30533576/?report=reader!6275967!30533576     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       ACS+Omega 2018 ; 3 (11): 15125-15133 Nephropedia Template TP {{tp|p=30533576|t=2018. Synthesis and Evaluation of Troponoids as a New Class of Antibiotics |pdf=|usr=}}{{30533576}} gab.com Text Synthesis and Evaluation of Troponoids as a New Class of Antibiotics JO: ACS Omega http://www.kidney.de/pget.php?&tw=1&pmid=30533576 #FOAvip Novel antibiotics are urgently needed. The troponoids [tropones, tropolones, and alpha-hydroxytropolones (alpha-HT)] can have anti-bacterial activity. We synthesized or purchased 92 troponoids and evaluated their antibacterial activities against Staphylococcus aureus, Escherichia coli, Acinetobacter baumannii, and Pseudomonas aeruginosa. Preliminary hits were assessed for minimum inhibitory concentrations (MIC(80)) and cytotoxicity (CC(50)) against human hepatoma cells. Sixteen troponoids inhibited S. aureus/E. coli/A. baumannii growth by >/=80% growth at <30 muM with CC(50) values >50 muM. Two selected tropolones (63 and 285) inhibited 18 methicillin-resistant S. aureus (MRSA) strains with similar MIC(80) values as against a reference strain. Two selected thiotropolones (284 and 363) inhibited multidrug-resistant (MDR) E. coli with MIC(80) </=30 muM. One alpha-HT (261) inhibited MDR-A. baumannii with MIC(80) </=30 muM. This study opens new avenues for development of novel troponoid antibiotics to address the critical need to combat MDR bacterial infections. Twit Text FOAVip Synthesis and Evaluation of Troponoids as a New Class of Antibiotics ????ACS Omega http://www.kidney.de/pget.php?&tw=1&pmid=30533576 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=30533576 #FOAvip English Wikipedia <ref>{{Cite pmid|30533576}}</ref> Synthesis and Evaluation of Troponoids as a New Class of Antibiotics #MMPMID30533576 Cao F; Orth C; Donlin MJ; Adegboyega P; Meyers MJ; Murelli RP; Elagawany M; Elgendy B; Tavis JE ACS Omega 2018[Nov]; 3 (11): 15125-15133 PMID30533576show ga Novel antibiotics are urgently needed. The troponoids [tropones, tropolones, and alpha-hydroxytropolones (alpha-HT)] can have anti-bacterial activity. We synthesized or purchased 92 troponoids and evaluated their antibacterial activities against Staphylococcus aureus, Escherichia coli, Acinetobacter baumannii, and Pseudomonas aeruginosa. Preliminary hits were assessed for minimum inhibitory concentrations (MIC(80)) and cytotoxicity (CC(50)) against human hepatoma cells. Sixteen troponoids inhibited S. aureus/E. coli/A. baumannii growth by >/=80% growth at <30 muM with CC(50) values >50 muM. Two selected tropolones (63 and 285) inhibited 18 methicillin-resistant S. aureus (MRSA) strains with similar MIC(80) values as against a reference strain. Two selected thiotropolones (284 and 363) inhibited multidrug-resistant (MDR) E. coli with MIC(80) äSynthesis and Evaluation of Troponoids as a New Class of Antibiotics (epmc).pdf DeepDyve Pubget Overpricing