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10.1684/mrh.2018.0439 http://scihub22266oqcxt.onion/10.1684/mrh.2018.0439 30530425!ä!30530425 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Magnes+Res 2018 ; 31 (3): 99-109 Nephropedia Template TP {{tp|p=30530425|t=2018. Varying magnesium concentration elicits changes in inflammatory response in human umbilical vein endothelial cells (HUVECs) |pdf=|usr=}}{{30530425}} gab.com Text Varying magnesium concentration elicits changes in inflammatory response in human umbilical vein endothelial cells (HUVECs) JO: Magnes Res http://www.kidney.de/pget.php?&tw=1&pmid=30530425 #FOAvip The aims of this study were to determine whether low concentrations of magnesium in vitro exacerbated the human umbilical vein endothelial cell (HUVEC) response to inflammatory challenge, and whether expression of the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappaB) through the toll-like receptor 4 (TLR4) played a role in this process. HUVECs were incubated with different concentrations of Mg (low- 0.1mM, control- 1mM, high- 5mM) for 72 h before being stimulated with bacterial lipopolysaccharide (LPS) for 4 h. The response of cells to LPS was greater in cells cultured in low Mg, relative to control cells and suppressed in high Mg. Expression of NF-kappaB was increased in low-Mg and decreased with high Mg. Low Mg increased the expression of TLR4 mRNA, but only in the presence of LPS. Antibody blockade of TLR4 but not TLR2 blunted the response of cells to LPS in low Mg, such that they were similar to unblocked 1mM Mg cells. Associations of Mg with cardiovascular disease may therefore relate to inflammatory responses mediated through the TLR4/NF-kappaB pathway. Twit Text FOAVip Varying magnesium concentration elicits changes in inflammatory response in human umbilical vein endothelial cells (HUVECs) ????Magnes Res http://www.kidney.de/pget.php?&tw=1&pmid=30530425 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=30530425 #FOAvip English Wikipedia <ref>{{Cite pmid|30530425}}</ref> Varying magnesium concentration elicits changes in inflammatory response in human umbilical vein endothelial cells (HUVECs) #MMPMID30530425 Almousa LA; Salter AM; Langley-Evans SC Magnes Res 2018[Aug]; 31 (3): 99-109 PMID30530425show ga The aims of this study were to determine whether low concentrations of magnesium in vitro exacerbated the human umbilical vein endothelial cell (HUVEC) response to inflammatory challenge, and whether expression of the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappaB) through the toll-like receptor 4 (TLR4) played a role in this process. HUVECs were incubated with different concentrations of Mg (low- 0.1mM, control- 1mM, high- 5mM) for 72 h before being stimulated with bacterial lipopolysaccharide (LPS) for 4 h. The response of cells to LPS was greater in cells cultured in low Mg, relative to control cells and suppressed in high Mg. Expression of NF-kappaB was increased in low-Mg and decreased with high Mg. Low Mg increased the expression of TLR4 mRNA, but only in the presence of LPS. Antibody blockade of TLR4 but not TLR2 blunted the response of cells to LPS in low Mg, such that they were similar to unblocked 1mM Mg cells. Associations of Mg with cardiovascular disease may therefore relate to inflammatory responses mediated through the TLR4/NF-kappaB pathway. |Antibodies, Neutralizing/immunology[MESH] |Culture Media[MESH] |Dose-Response Relationship, Drug[MESH] |Endothelium, Vascular/*drug effects/*immunology[MESH] |Gene Expression/drug effects[MESH] |Human Umbilical Vein Endothelial Cells[MESH] |Humans[MESH] |Lipopolysaccharides/immunology[MESH] |Magnesium/*pharmacology[MESH] |NF-kappa B/*genetics/immunology[MESH] |Primary Cell Culture[MESH] |RNA, Messenger/genetics[MESH] |Signal Transduction[MESH]Varying magnesium concentration elicits changes in inflammatory respon(epmc).pdf DeepDyve Pubget Overpricing