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10.1007/s12012-018-9498-3 http://scihub22266oqcxt.onion/10.1007/s12012-018-9498-3 30523498!6505488!30523498     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=30523498&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 259.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 259.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 259.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 259.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 259.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 259.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 259.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cardiovasc+Toxicol 2019 ; 19 (3): 276-286 Nephropedia Template TP {{tp|p=30523498|t=2019. Cobalt Administration Causes Reduced Contractility with Parallel Increases in TRPC6 and TRPM7 Transporter Protein Expression in Adult Rat Hearts |pdf=|usr=}}{{30523498}} gab.com Text Cobalt Administration Causes Reduced Contractility with Parallel Increases in TRPC6 and TRPM7 Transporter Protein Expression in Adult Rat Hearts JO: Cardiovasc Toxicol http://www.kidney.de/pget.php?&tw=1&pmid=30523498 #FOAvip Exposure to circulating cobalt (Co(2+)) in patients with metal-on-metal orthopaedic hip implants has been linked to cardiotoxicity but the underlying mechanism(s) remain undefined. The aim of the current study was to examine the effects of Co(2+) on the heart in vivo and specifically on cardiac fibroblasts in vitro. Adult male rats were treated with CoCl(2) (1 mg/kg) for either 7 days or 28 days. Inductively coupled plasma mass spectrometry (ICP-MS) was used to measure Co(2+) uptake into various organs of the body. Co(2+) accumulated in the heart over time with significant levels evident after only 7 days of treatment. There was no evidence of cardiac remodelling following Co(2+) treatment as assessed by heart weight:body weight and left ventricular weight:body weight. However, a decrease in fractional shortening, as measured using echocardiography, was observed after 28 days of Co(2+) treatment. This was accompanied by increased protein expression of the ion transient receptor potential (TRP) channels TRPC6 and TRPM7 as assessed by quantitative immunoblotting of whole cardiac homogenates. Uptake of Co(2+) specifically into rat cardiac fibroblasts was measured over 72 h and was shown to dramatically increase with increasing concentrations of applied CoCl(2). Expression levels of TRPC6 and TRPM7 proteins were both significantly elevated in these cells following Co(2+) treatment. In conclusion, Co(2+) rapidly accumulates to significant levels in the heart causing compromised contractility in the absence of any overt cardiac remodelling. TRPC6 and TRPM7 expression levels are significantly altered in the heart following Co(2+) treatment and this may contribute to the Co(2+)-induced cardiotoxicity observed over time. Twit Text FOAVip Cobalt Administration Causes Reduced Contractility with Parallel Increases in TRPC6 and TRPM7 Transporter Protein Expression in Adult Rat Hearts ????Cardiovasc Toxicol http://www.kidney.de/pget.php?&tw=1&pmid=30523498 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=30523498 #FOAvip English Wikipedia <ref>{{Cite pmid|30523498}}</ref> Cobalt Administration Causes Reduced Contractility with Parallel Increases in TRPC6 and TRPM7 Transporter Protein Expression in Adult Rat Hearts #MMPMID30523498 Laovitthayanggoon S; Henderson CJ; McCluskey C; MacDonald M; Tate RJ; Grant MH; Currie S Cardiovasc Toxicol 2019[Jun]; 19 (3): 276-286 PMID30523498show ga Exposure to circulating cobalt (Co(2+)) in patients with metal-on-metal orthopaedic hip implants has been linked to cardiotoxicity but the underlying mechanism(s) remain undefined. The aim of the current study was to examine the effects of Co(2+) on the heart in vivo and specifically on cardiac fibroblasts in vitro. Adult male rats were treated with CoCl(2) (1 mg/kg) for either 7 days or 28 days. Inductively coupled plasma mass spectrometry (ICP-MS) was used to measure Co(2+) uptake into various organs of the body. Co(2+) accumulated in the heart over time with significant levels evident after only 7 days of treatment. There was no evidence of cardiac remodelling following Co(2+) treatment as assessed by heart weight:body weight and left ventricular weight:body weight. However, a decrease in fractional shortening, as measured using echocardiography, was observed after 28 days of Co(2+) treatment. This was accompanied by increased protein expression of the ion transient receptor potential (TRP) channels TRPC6 and TRPM7 as assessed by quantitative immunoblotting of whole cardiac homogenates. Uptake of Co(2+) specifically into rat cardiac fibroblasts was measured over 72 h and was shown to dramatically increase with increasing concentrations of applied CoCl(2). Expression levels of TRPC6 and TRPM7 proteins were both significantly elevated in these cells following Co(2+) treatment. In conclusion, Co(2+) rapidly accumulates to significant levels in the heart causing compromised contractility in the absence of any overt cardiac remodelling. TRPC6 and TRPM7 expression levels are significantly altered in the heart following Co(2+) treatment and this may contribute to the Co(2+)-induced cardiotoxicity observed over time. |Animals[MESH] |Cardiotoxicity[MESH] |Cells, Cultured[MESH] |Cobalt/*toxicity[MESH] |Fibroblasts/*drug effects/metabolism/pathology[MESH] |Heart Diseases/*chemically induced/metabolism/pathology/physiopathology[MESH] |Heart Ventricles/*drug effects/metabolism/pathology/physiopathology[MESH] |Male[MESH] |Myocardial Contraction/*drug effects[MESH] |Rats, Sprague-Dawley[MESH] |Signal Transduction[MESH] |TRPC Cation Channels/*metabolism[MESH] |TRPM Cation Channels/*metabolism[MESH] |Time Factors[MESH] |Up-Regulation[MESH]Cobalt Administration Causes Reduced Contractility with Parallel Incre(epmc).pdf DeepDyve Pubget Overpricing