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10.1111/sji.12738 http://scihub22266oqcxt.onion/10.1111/sji.12738 30506563!ä!30506563 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Scand+J+Immunol 2019 ; 89 (2): e12738 Nephropedia Template TP {{tp|p=30506563|t=2019. Monoclonal antibody against human Tim-3 enhances antiviral immune response |pdf=|usr=}}{{30506563}} gab.com Text Monoclonal antibody against human Tim-3 enhances antiviral immune response JO: Scand J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=30506563 #FOAvip T cell immunoglobulin and mucin domain protein 3 (Tim-3) is an immune checkpoint inhibitor in T cells and innate immune cells. The deregulated upregulation of Tim-3 is related to immune exhaustion in tumour and viral infection. To overcome Tim-3-mediated immune tolerance, we developed a novel monoclonal antibody against human Tim-3 (L3G) and investigated its roles in inhibiting Tim-3 signalling and overcoming immune tolerance in T cells and monocytes/macrophages. The administration of L3G to cultured peripheral blood mononuclear cells (PBMCs) significantly increased the production of IFN-gamma and IL-2 and the expression of type I interferon. The administration of L3G also increased the production of IFN-gamma, IL-8 and type I interferon in U937 cells and primary monocytes. We investigated the mechanisms by which L3G enhances pro-inflammatory cytokine expression, and our data show that L3G enhances STAT1 phosphorylation in both monocytes/macrophages and T cells. Finally, in an H1N1 infection model of PBMCs and U937 cells, L3G decreased the viral load and enhanced the expression of interferon. Thus, we developed a functional antibody with therapeutic potential against Tim-3-mediated infection tolerance. Twit Text FOAVip Monoclonal antibody against human Tim-3 enhances antiviral immune response ????Scand J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=30506563 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=30506563 #FOAvip English Wikipedia <ref>{{Cite pmid|30506563}}</ref> Monoclonal antibody against human Tim-3 enhances antiviral immune response #MMPMID30506563 Li G; Hou C; Dou S; Zhang J; Zhang Y; Liu Y; Wang Z; Xiao H; Wang R; Chen G; Li Y; Feng J; Shen B; Han G Scand J Immunol 2019[Feb]; 89 (2): e12738 PMID30506563show ga T cell immunoglobulin and mucin domain protein 3 (Tim-3) is an immune checkpoint inhibitor in T cells and innate immune cells. The deregulated upregulation of Tim-3 is related to immune exhaustion in tumour and viral infection. To overcome Tim-3-mediated immune tolerance, we developed a novel monoclonal antibody against human Tim-3 (L3G) and investigated its roles in inhibiting Tim-3 signalling and overcoming immune tolerance in T cells and monocytes/macrophages. The administration of L3G to cultured peripheral blood mononuclear cells (PBMCs) significantly increased the production of IFN-gamma and IL-2 and the expression of type I interferon. The administration of L3G also increased the production of IFN-gamma, IL-8 and type I interferon in U937 cells and primary monocytes. We investigated the mechanisms by which L3G enhances pro-inflammatory cytokine expression, and our data show that L3G enhances STAT1 phosphorylation in both monocytes/macrophages and T cells. Finally, in an H1N1 infection model of PBMCs and U937 cells, L3G decreased the viral load and enhanced the expression of interferon. Thus, we developed a functional antibody with therapeutic potential against Tim-3-mediated infection tolerance. |Animals[MESH] |Antibodies, Monoclonal/*metabolism[MESH] |Cytokines/metabolism[MESH] |Disease Models, Animal[MESH] |Female[MESH] |Hepatitis A Virus Cellular Receptor 2/*immunology[MESH] |Humans[MESH] |Inflammation Mediators/metabolism[MESH] |Influenza A Virus, H1N1 Subtype/*physiology[MESH] |Influenza, Human/*immunology[MESH] |Lymphocyte Activation[MESH] |Macrophages/*immunology/virology[MESH] |Mice[MESH] |Mice, Inbred BALB C[MESH] |Orthomyxoviridae Infections/*immunology[MESH] |STAT1 Transcription Factor/metabolism[MESH] |Signal Transduction[MESH] |T-Lymphocytes/*immunology[MESH] |U937 Cells[MESH]Monoclonal antibody against human Tim-3 enhances antiviral immune resp(epmc).pdf DeepDyve Pubget Overpricing