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10.15252/emmm.201809528 http://scihub22266oqcxt.onion/10.15252/emmm.201809528 30498026!6328914!30498026     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       EMBO+Mol+Med 2019 ; 11 (1): ä Nephropedia Template TP {{tp|p=30498026|t=2019. Identification and characterization of GLDC as host susceptibility gene to severe influenza |pdf=|usr=}}{{30498026}} gab.com Text Identification and characterization of GLDC as host susceptibility gene to severe influenza JO: EMBO Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=30498026 #FOAvip Glycine decarboxylase (GLDC) was prioritized as a candidate susceptibility gene to severe influenza in humans. The higher expression of GLDC derived from genetic variations may confer a higher risk to H7N9 and severe H1N1 infection. We sought to characterize GLDC as functional susceptibility gene that GLDC may intrinsically regulate antiviral response, thereby impacting viral replication and disease outcome. We demonstrated that GLDC inhibitor AOAA and siRNA depletion boosted IFNbeta- and IFN-stimulated genes (ISGs) in combination with PolyI:C stimulation. GLDC inhibition and depletion significantly amplified antiviral response of type I IFNs and ISGs upon viral infection and suppressed the replication of H1N1 and H7N9 viruses. Consistently, GLDC overexpression significantly promoted viral replication due to the attenuated antiviral responses. Moreover, GLDC inhibition in H1N1-infected BALB/c mice recapitulated the amplified antiviral response and suppressed viral growth. AOAA provided potent protection to the infected mice from lethal infection, comparable to a standard antiviral against influenza viruses. Collectively, GLDC regulates cellular antiviral response and orchestrates viral growth. GLDC is a functional susceptibility gene to severe influenza in humans. Twit Text FOAVip Identification and characterization of GLDC as host susceptibility gene to severe influenza ????EMBO Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=30498026 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=30498026 #FOAvip English Wikipedia <ref>{{Cite pmid|30498026}}</ref> Identification and characterization of GLDC as host susceptibility gene to severe influenza #MMPMID30498026 Zhou J; Wang D; Wong BH; Li C; Poon VK; Wen L; Zhao X; Chiu MC; Liu X; Ye Z; Yuan S; Sze KH; Chan JF; Chu H; To KK; Yuen KY EMBO Mol Med 2019[Jan]; 11 (1): ä PMID30498026show ga Glycine decarboxylase (GLDC) was prioritized as a candidate susceptibility gene to severe influenza in humans. The higher expression of GLDC derived from genetic variations may confer a higher risk to H7N9 and severe H1N1 infection. We sought to characterize GLDC as functional susceptibility gene that GLDC may intrinsically regulate antiviral response, thereby impacting viral replication and disease outcome. We demonstrated that GLDC inhibitor AOAA and siRNA depletion boosted IFNbeta- and IFN-stimulated genes (ISGs) in combination with PolyI:C stimulation. GLDC inhibition and depletion significantly amplified antiviral response of type I IFNs and ISGs upon viral infection and suppressed the replication of H1N1 and H7N9 viruses. Consistently, GLDC overexpression significantly promoted viral replication due to the attenuated antiviral responses. Moreover, GLDC inhibition in H1N1-infected BALB/c mice recapitulated the amplified antiviral response and suppressed viral growth. AOAA provided potent protection to the infected mice from lethal infection, comparable to a standard antiviral against influenza viruses. Collectively, GLDC regulates cellular antiviral response and orchestrates viral growth. GLDC is a functional susceptibility gene to severe influenza in humans. |*Genetic Predisposition to Disease[MESH] |*Immunity, Innate[MESH] |Animals[MESH] |Disease Models, Animal[MESH] |Enzyme Inhibitors/administration & dosage[MESH] |Glycine Dehydrogenase (Decarboxylating)/*genetics[MESH] |Humans[MESH] |Influenza A Virus, H1N1 Subtype/growth & development/immunology[MESH] |Influenza A Virus, H7N9 Subtype/growth & development/immunology[MESH] |Influenza, Human/*genetics/pathology[MESH] |Mice, Inbred BALB C[MESH] |Orthomyxoviridae Infections/drug therapy/pathology[MESH] |Tacrolimus/administration & dosage/analogs & derivatives[MESH] |Treatment Outcome[MESH]Identification and characterization of GLDC as host susceptibility gen(epmc).pdf DeepDyve Pubget Overpricing