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StatPearls-/-? 2025[Jan]; ? (?): ? PMID30484997show ga
Nalbuphine is a synthetic opioid analgesic indicated for the management of moderate to severe pain when alternative treatments prove inadequate. This educational activity reviews nalbuphine's FDA-approved indications, proper administration, and relevant contraindications and precautions. Emphasis is placed on nalbuphine's pharmacodynamic and pharmacokinetic properties, including its mixed agonist-antagonist profile, which impacts both therapeutic benefits and adverse event risks. The boxed warning regarding coadministration with benzodiazepines is addressed in detail, highlighting the potential for life-threatening respiratory depression, sedation, coma, and death.