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10.5414/CN109442 http://scihub22266oqcxt.onion/10.5414/CN109442 30474593!?!30474593 Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=30474593&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Clin+Nephrol 2019 ; 91 (2): 79-86 Nephropedia Template TP {{tp|p=30474593|t=2019. Corticosteroid therapy alone for the treatment of C3 glomerulonephritis in association with monoclonal gammopathy? |pdf=|usr=}}{{30474593}} gab.com Text Corticosteroid therapy alone for the treatment of C3 glomerulonephritis in association with monoclonal gammopathy JO: Clin Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=30474593 #FOAvip INTRODUCTION: C3 glomerulonephritis (C3GN) is a form of proliferative glomerulonephritis characterized by dominant glomerular C3 deposition. There is currently no consensus guideline on therapy for this disease. Experience with corticosteroids alone is scant in C3GN. We report the experience of treating patients with C3GN in association with monoclonal gammopathy with corticosteroid at a single center. MATERIALS AND METHODS: Corticosteroid therapy alone was used to treat 6 patients with C3GN who were also found to have monoclonal gammopathy at the time of presentation. RESULTS: Median age of this cohort was 65 years. Median estimated glomerular filtration rate (eGFR) by MDRD equation was 31.6 mL/min/1.73m(2) at presentation. After a median duration of follow-up of 23.5 months, all patients showed improvement in proteinuria: median proteinuria reduced from 2.3 to 0.5 g/d. Four of 6 patients showed improvement in kidney function. One patient who had required renal replacement therapy recovered renal function. Median eGFR at follow-up was 38.7 mL/min/1.73m(2). DISCUSSION: In patients with C3GN in association with monoclonal gammopathy, corticosteroid therapy alone may be a viable treatment option. Work-up should be done to exclude a hematologic neoplasm and inherited complement abnormalities before proceeding to corticosteroid therapy.?. Twit Text FOAVip Corticosteroid therapy alone for the treatment of C3 glomerulonephritis in association with monoclonal gammopathy ????Clin Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=30474593 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=30474593 #FOAvip English Wikipedia <ref>{{Cite pmid|30474593}}</ref> Corticosteroid therapy alone for the treatment of C3 glomerulonephritis in association with monoclonal gammopathy? #MMPMID30474593 Sathick IJ; Zand L; Nasr SH; Leung N Clin Nephrol 2019[Feb]; 91 (2): 79-86 PMID30474593show ga INTRODUCTION: C3 glomerulonephritis (C3GN) is a form of proliferative glomerulonephritis characterized by dominant glomerular C3 deposition. There is currently no consensus guideline on therapy for this disease. Experience with corticosteroids alone is scant in C3GN. We report the experience of treating patients with C3GN in association with monoclonal gammopathy with corticosteroid at a single center. MATERIALS AND METHODS: Corticosteroid therapy alone was used to treat 6 patients with C3GN who were also found to have monoclonal gammopathy at the time of presentation. RESULTS: Median age of this cohort was 65 years. Median estimated glomerular filtration rate (eGFR) by MDRD equation was 31.6 mL/min/1.73m(2) at presentation. After a median duration of follow-up of 23.5 months, all patients showed improvement in proteinuria: median proteinuria reduced from 2.3 to 0.5 g/d. Four of 6 patients showed improvement in kidney function. One patient who had required renal replacement therapy recovered renal function. Median eGFR at follow-up was 38.7 mL/min/1.73m(2). DISCUSSION: In patients with C3GN in association with monoclonal gammopathy, corticosteroid therapy alone may be a viable treatment option. Work-up should be done to exclude a hematologic neoplasm and inherited complement abnormalities before proceeding to corticosteroid therapy.?. |Adrenal Cortex Hormones/*therapeutic use[MESH] |Aged[MESH] |Complement C3/metabolism[MESH] |Female[MESH] |Glomerular Filtration Rate[MESH] |Glomerulonephritis, Membranoproliferative/*complications/*drug therapy/metabolism/physiopathology[MESH] |Humans[MESH] |Male[MESH] |Middle Aged[MESH] |Paraproteinemias/*complications[MESH] |Proteinuria/etiology[MESH]Corticosteroid therapy alone for the treatment of C3 glomerulonephriti(epmc).pdf DeepDyve Pubget Overpricing