Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1080/1061186X.2018.1550648 http://scihub22266oqcxt.onion/10.1080/1061186X.2018.1550648 30457021!ä!30457021 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Drug+Target 2019 ; 27 (4): 460-465 Nephropedia Template TP {{tp|p=30457021|t=2019. PDK2 induces cisplatin-resistance in lung adenocarcinoma via transcriptional regulation of CNNM3 |pdf=|usr=}}{{30457021}} gab.com Text PDK2 induces cisplatin-resistance in lung adenocarcinoma via transcriptional regulation of CNNM3 JO: J Drug Target http://www.kidney.de/pget.php?&tw=1&pmid=30457021 #FOAvip Recurrence of lung adenocarcinoma has become one of the most frequent causes of major cancer incidence and mortality worldwide according to its frequently gained resistance to chemotherapies. In this study, we identified a poorly-studied kinase pyruvate dehydrogenase kinase isoform 2 (PDK2) as the most up-regulated kinase encoding gene in Cisplatin resistant lung adenocarcinoma. Additionally, PDK2-dependent Cisplatin-resistance promotes tumour growth of lung adenocarcinoma both in vitro and in vivo. Clinically, PDK2 expression was up-regulated in lung adenocarcinoma and was correlated to the poor prognosis of lung cancer patients. Mechanically, PDK2 promoted cell growth and Cisplatin-resistance of lung adenocarcinoma via transcriptional regulation of cyclin and CBS domain divalent metal cation transport mediator 3 (CNNM3), indicating that PDK2-CNNM3 signalling axis could be a potential therapeutic target for Cisplatin-resistant lung adenocarcinoma. Twit Text FOAVip PDK2 induces cisplatin-resistance in lung adenocarcinoma via transcriptional regulation of CNNM3 ????J Drug Target http://www.kidney.de/pget.php?&tw=1&pmid=30457021 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=30457021 #FOAvip English Wikipedia <ref>{{Cite pmid|30457021}}</ref> PDK2 induces cisplatin-resistance in lung adenocarcinoma via transcriptional regulation of CNNM3 #MMPMID30457021 Hu T; Yu S; Li Y; Ren H; Ning Q; Wang J; Liang X; Li M J Drug Target 2019[Apr]; 27 (4): 460-465 PMID30457021show ga Recurrence of lung adenocarcinoma has become one of the most frequent causes of major cancer incidence and mortality worldwide according to its frequently gained resistance to chemotherapies. In this study, we identified a poorly-studied kinase pyruvate dehydrogenase kinase isoform 2 (PDK2) as the most up-regulated kinase encoding gene in Cisplatin resistant lung adenocarcinoma. Additionally, PDK2-dependent Cisplatin-resistance promotes tumour growth of lung adenocarcinoma both in vitro and in vivo. Clinically, PDK2 expression was up-regulated in lung adenocarcinoma and was correlated to the poor prognosis of lung cancer patients. Mechanically, PDK2 promoted cell growth and Cisplatin-resistance of lung adenocarcinoma via transcriptional regulation of cyclin and CBS domain divalent metal cation transport mediator 3 (CNNM3), indicating that PDK2-CNNM3 signalling axis could be a potential therapeutic target for Cisplatin-resistant lung adenocarcinoma. |Adenocarcinoma of Lung/*drug therapy[MESH] |Animals[MESH] |Antineoplastic Agents/pharmacology[MESH] |Cell Line, Tumor[MESH] |Cisplatin/*pharmacology[MESH] |Cyclins/genetics[MESH] |Drug Resistance, Neoplasm[MESH] |Female[MESH] |Humans[MESH] |Lung Neoplasms/*drug therapy[MESH] |Mice[MESH] |Mice, Nude[MESH] |Pyruvate Dehydrogenase Acetyl-Transferring Kinase/*genetics[MESH] |Up-Regulation[MESH]PDK2 induces cisplatin-resistance in lung adenocarcinoma via transcrip(epmc).pdf DeepDyve Pubget Overpricing