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Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Arch+Physiol+Biochem 2020 ; 126 (3): 196-200 Nephropedia Template TP
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Pretreatment of simvastatin on liver trace element levels during endotoxemia #MMPMID30450988
Yorulmaz H; Ozkok E; Demir G; Ertugrul Yalcin I; Ates G; Olgac V; Tamer S
Arch Physiol Biochem 2020[Jul]; 126 (3): 196-200 PMID30450988show ga
There are a number of studies investigating anti-inflammatory effects of simvastatin in patients with sepsis and animal models. There are a few studies which investigated effect of simvastatin on elements in sepsis. In the present study, the impact of pretreatment with simvastatin on element levels was evaluated in liver during endotoxemia. Rats were divided into control, LPS, simvastatin, and simvastatin + LPS. The histopathologic examination of the liver was performed using hematoxylin and eosin. Selenium, zinc, iron, manganese, magnesium, and copper were analyzed using inductively coupled plasma - optical emission spectroscopy. In the LPS, the hepatocyte cell structure was damaged. In the simvastatin + LPS, hepatocyte, and sinusoidal cord damage were partially smaller than LPS. Levels of selenium, and copper significantly decreased in both of LPS and simvastatin + LPS. In the LPS group, iron was found to increase. In the simvastatin + LPS, zinc was increased. Simvastatin partially smaller liver damage by increasing zinc levels during endotoxemia.
Arch+Physiol+Biochem 2020 ; 126 (3): 196-200
