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10.1159/000494762 http://scihub22266oqcxt.onion/10.1159/000494762 30448832!ä!30448832 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Pharmacology 2019 ; 103 (1-2): 61-67 Nephropedia Template TP {{tp|p=30448832|t=2019. Propranolol Suppresses Cobalt Chloride-Induced Hypoxic Proliferation in Human Umbilical Vein Endothelial Cells in vitro |pdf=|usr=}}{{30448832}} gab.com Text Propranolol Suppresses Cobalt Chloride-Induced Hypoxic Proliferation in Human Umbilical Vein Endothelial Cells in vitro JO: Pharmacology http://www.kidney.de/pget.php?&tw=1&pmid=30448832 #FOAvip BACKGROUND/AIMS: To investigate the effect of propranolol on cobalt chloride (CoCl2)-induced hypoxic proliferation in human umbilical vein endothelial cells (HUVECs). METHODS: CoCl2 was administrated to HUVECs to mimic hypoxic proliferation in infantile hemangioma. The proliferation of HUVECs was detected by Cell Counting Kit-8. Effects of propranolol on apoptosis and expressions of cell cycle-related genes, CDK4 and cyclin D1, were detected by flow cytometry and RT-PCR respectively. The release of vascular endothelial growth factor (VEGF) and lactate dehydrogenase (LDH) was measured by enzyme-linked immunosorbent assay. RESULTS: Propranolol significantly inhibited the CoCl2-induced hypoxic proliferation of HUVECs in a dose-dependent manner, and also induced apoptosis and suppressed the expression of CDK4 and cyclin D1. Propranolol also decreased the release of VEGF and LDH in the supernatant. CONCLUSIONS: Propranolol could inhibit CoCl2-induced hypoxic proliferation of HUVECs through inducing apoptosis and cell cycle arrest. Twit Text FOAVip Propranolol Suppresses Cobalt Chloride-Induced Hypoxic Proliferation in Human Umbilical Vein Endothelial Cells in vitro ????Pharmacology http://www.kidney.de/pget.php?&tw=1&pmid=30448832 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=30448832 #FOAvip English Wikipedia <ref>{{Cite pmid|30448832}}</ref> Propranolol Suppresses Cobalt Chloride-Induced Hypoxic Proliferation in Human Umbilical Vein Endothelial Cells in vitro #MMPMID30448832 Wei L; Li L; Zhang B; Ma L Pharmacology 2019[]; 103 (1-2): 61-67 PMID30448832show ga BACKGROUND/AIMS: To investigate the effect of propranolol on cobalt chloride (CoCl2)-induced hypoxic proliferation in human umbilical vein endothelial cells (HUVECs). METHODS: CoCl2 was administrated to HUVECs to mimic hypoxic proliferation in infantile hemangioma. The proliferation of HUVECs was detected by Cell Counting Kit-8. Effects of propranolol on apoptosis and expressions of cell cycle-related genes, CDK4 and cyclin D1, were detected by flow cytometry and RT-PCR respectively. The release of vascular endothelial growth factor (VEGF) and lactate dehydrogenase (LDH) was measured by enzyme-linked immunosorbent assay. RESULTS: Propranolol significantly inhibited the CoCl2-induced hypoxic proliferation of HUVECs in a dose-dependent manner, and also induced apoptosis and suppressed the expression of CDK4 and cyclin D1. Propranolol also decreased the release of VEGF and LDH in the supernatant. CONCLUSIONS: Propranolol could inhibit CoCl2-induced hypoxic proliferation of HUVECs through inducing apoptosis and cell cycle arrest. |Apoptosis/drug effects[MESH] |Caspase 3/metabolism[MESH] |Cell Hypoxia/*drug effects[MESH] |Cell Proliferation/drug effects[MESH] |Cell Survival/drug effects[MESH] |Cells, Cultured[MESH] |Cobalt/*pharmacology[MESH] |Cyclin D1/metabolism[MESH] |Cyclin-Dependent Kinase 4/metabolism[MESH] |Drug Interactions[MESH] |Human Umbilical Vein Endothelial Cells/cytology/*drug effects/metabolism[MESH] |Humans[MESH] |L-Lactate Dehydrogenase/metabolism[MESH] |Propranolol/*pharmacology[MESH] |Proto-Oncogene Proteins c-bcl-2/metabolism[MESH] |Vascular Endothelial Growth Factor A/metabolism[MESH]Propranolol Suppresses Cobalt Chloride-Induced Hypoxic Proliferation i(epmc).pdf DeepDyve Pubget Overpricing